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merck millipore,默克密理博,06-659,Anti-phospho-c-Jun (Ser73) Antibody
产品名称：Anti-phospho-c-Jun (Ser73) Antibody
产品型号：06-659
Anti-phospho-c-Jun (Ser73) Antibody is a Rabbit Polyclonal Antibody for detection of phospho-c-Jun (Ser73) also known as Activator protein 1 & has been validated in ICC, IP & WB.
merck millipore,默克密理博,06-659,Anti-phospho-c-Jun (Ser73) Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H, M WB, ICC Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 06-659 Replaces 04-213 品牌系列 Upstate
商名 - Upstate
描述 Anti-phospho-c-Jun (Ser73) Antibody Alternate Names - v-jun sarcoma virus 17 oncogene homolog (avian)
- Activator protein 1
- Jun activation domain binding protein
- Proto-oncogene c-jun
- V-jun avian sarcoma virus 17 oncogene homolog
- enhancer-binding protein AP1
- jun oncogene
- v-jun sarcoma virus 17 oncogene homolog
背景信息 c-Jun is a component of the transcription factor AP-1 that binds and activates transcription at TRE/AP-1 elements and appears to be a major downstream target of the SAPK/JNK signaling pathway. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73. Extracellular signals including growth factors, transforming oncoproteins and UV irradiation stimulate phosphorylation of c-Jun at Ser63/73 and activate c-Jun dependent transcription. Mutation of Ser63/73 renders c-Jun nonresponsive to mitogenic and stress induced
signaling pathways. The MAP kinase homologue, SAPK/JNK, binds to the N-terminal region of c-Jun and phosphorylates c-Jun at Ser63/73. In addition, the activity of SAPK/JNK is stimulated by the same signals that activate c-Jun.产品信息 格式 Affinity Purified 控制 - Untreated and anisomycin-treated NIH/3T3 cell lysate.
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-phospho-c-Jun (Ser73) Antibody is a Rabbit Polyclonal Antibody for detection of phospho-c-Jun (Ser73) also known as Activator protein 1 & has been validated in ICC, IP & WB. 主要应用 - Western Blotting
- Immunocytochemistry
应用说明 Western Blot Analysis :
A previous lot of this antibody detected 10 ng of phosphorylated gst-Jun, but did not detect 10 ng of nonphosphorylated Jun, as reported by an independent laboratory.
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the human Phospho-C-Jun (Ser73) near the N-terminus. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody detects phospho-c-Jun. May also detect phospho-JunD in properly treated cells since the sequence homology is identical (13/13). 品种反应性 HumanMouse Species Reactivity Note Human, Mouse. Predicted to react with Rat, Bovine, Chicken, Zebrafish, Xenopus based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_002219.1
Entrez基因汇总 This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. 基因符号 - c-Jun
- JUN
- p39
- AP1
修改 - Phosphorylation
纯化方法 Affinity Purfied UniProt编号 - P05412
产品使用声明 质量保证 Evaluated by Western Blotting in Anisomycin treated NIH/3T3 cell lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Phospho-C-Jun (Ser73) in 10 µg of Anisomycin treated NIH/3T3 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain for 1 year at 2 to 8°C from date of shipment. 包装信息 数量 100 µL
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