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merck millipore,默克密理博,528106,PI 3-Kγ Inhibitor - CAS 648450-29-7 - Calbiochem
产品名称：PI 3-Kγ Inhibitor - CAS 648450-29-7 - Calbiochem
产品型号：528106
The PI 3-Kγ Inhibitor, also referenced under CAS 648450-29-7, controls the biological activity of PI 3-Kγ. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation appli More>>
merck millipore,默克密理博,528106,PI 3-Kγ Inhibitor - CAS 648450-29-7 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₂H₇N₃O₂S 648450-29-7 描述 概述 A cell-permeable thiazolidinedione compound that acts as a potent, selective, and ATP-competitive inhibitor of phosphatidylinositol 3-kinase γ (PI 3-Kγ) (Ki = 7.8 nM; IC50 = 8 nM, 60 nM, 270 nM, 300 nM for p110-γ, α, β and δ-isoforms, respectively). Does not affect the activity of a wide panel of kinases, receptors, enzymes, and ion channels even at concentrations as high as 1 µM. Selectively blocks MCP-1-, but not CSF-1-, dependent Akt phosphorylation and chemotaxis in primary Pik3cg+/+ murine monocytes and in a human monocytic cell line THP-1 (IC50 = 181 nM). Also shown to exhibit in vivo efficacy in reducing neutrophil chemotaxis in murine peritonitis and arthritis models. 产品目录编号 528106 品牌系列 Calbiochem®
同义词 5-Quinoxalin-6-ylmethylene-thiazolidine-2,4-dione, PI 3-K Inhibitor I 参考 参考 Barber, D.F., et al. 2005. Nat. Med. 11, 933.
Camps, M., et al. 2005. Nat. Med. 11, 936.产品信息 CAS号 648450-29-7 具有ATP竞争性 Y 形式 Pink solid Hill配方 C₁₂H₇N₃O₂S 化学配方 C₁₂H₇N₃O₂S Molar Mass 257.3 可逆 N 结构配方图像 生物信息 主靶 Phosphatidylinositol 3-kinase γ (PI 3-Kγ) 主靶IC50 8 nM, 60 nM, 270 nM, 300 nM for p110-γ, α, β and δ-isoforms, respectively; 181 nM in selectively blocking MCP-1-, but not CSF-1-, dependent Akt phosphorylation and chemotaxis in primary Pik3cg+/+ murine monocytes and in a human mono 主靶Ki 7.8 nM 纯度 ≥90% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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