merck millipore,默克密理博,06-600,Anti-NR2B Antibody

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merck millipore,默克密理博,06-600,Anti-NR2B Antibody
产品名称：Anti-NR2B Antibody
产品型号：06-600
Detect NR2B using this Anti-NR2B Antibody validated for use in IC, IP & WB.

merck millipore,默克密理博,06-600,Anti-NR2B Antibody

产品介绍

merck millipore,默克密理博,06-600,Anti-NR2B Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
R, B, Ca, H, Mk	WB, ICC	Rb	Purified	Polyclonal Antibody

描述
产品目录编号	06-600
品牌系列	Upstate
商名	Upstate
描述	Anti-NR2B Antibody
Alternate Names	glutamate receptor, ionotropic, N-methyl D-aspartate 2B N-methyl D-aspartate receptor subtype 2B N-methyl-D-aspartate receptor subunit 2B N-methyl-D-aspartate receptor subunit 3 glutamate receptor subunit epsilon-2 glutamate receptor ionotropic
背景信息	NMDA receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long term potentiation, an activity dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B or NR2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). GRIN2B may be a candidate gene for the neurodegenerative disorder dentato-rubro-pallidoluysian atrophy (DRPLA). Properties of NMDAR include modulation by glycine, inhibition by Zn2+, voltage dependent Mg2+ blockade and high Ca2+ permeability. The involvement of NMDAR in the CNS has become a focus area for neurodegenerative diseases such as Alzheimer's disease, epilepsy and ischemic neuronal cell death.

产品信息
格式	Purified
控制	Mouse brain tissue
演示	Purified rabbit polyclonal IgG in buffer containing 0.1 M Tris-Glycine, 0.15 M NaCl, and 0.05% sodium azide. Frozen solution.

应用
应用	Detect NR2B using this Anti-NR2B Antibody validated for use in IC, IP & WB.
主要应用	Western Blotting Immunocytochemistry

生物信息
免疫原品种	a.a. 1437-1456 of mature mouse NR2B or 1463-1482 of NR2B precursor; signal is a.a. residues 1-26 [KFNGSSNG HVYEKLSSIESDV]. This sequence is identical to a.a. 1437-1456 of mature rat NR2B and a.a. 1465-1484 of human NR3, containing a N-terminal lysine.
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rabbit
特异性	NR2B; the immungen sequence is identical in mouse, rat, human, bovine, dog and chimp NR2B. Human NR2B is sometimes referred to as hNR3 in the literature.
同种型	IgG
品种反应性	RatBovineCanineHumanMonkey
Species Reactivity Note	Mouse. Other species unknown but based on the immunogenic sequence, this antibody may cross-react with rat NR2B and human NR3.
抗体类型	Polyclonal Antibody
Entrez基因编号	NM_008171
Entrez基因汇总	N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain.
基因符号	GRIN2B MGC142178 MGC142180 NMDAR2B NR3 hNR3
纯化方法	Protein A purfied
UniProt编号	Q13224
UniProt汇总	FUNCTION: SwissProt: Q13224 # NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. SIZE: 1484 amino acids; 166367 Da SUBUNIT: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of INADL and DLG4 (By similarity). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia. SIMILARITY: SwissProt: Q13224 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family.

产品使用声明
质量保证	Routinely evaluated by Western Blot on rat brain microsomal preparation (Catalog # 12-144). Western Blot Analysis: 0.5-2 μg/mL of this lot of antibody detected NR2B (~180 kDa) in rat brain microsomal preparation (Catalog # 12-144).
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20°C from date of receipt. Aliquot to avoid freezing and thawing. For maximum recovery of the product, centrifuge the original vial after thawing and prior to removing the cap. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

储存和货运信息

存储条件

Stable for 1 year at -20°C from date of receipt.
Aliquot to avoid freezing and thawing. For maximum recovery of the product, centrifuge the original vial after thawing and prior to removing the cap.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.