merck millipore,默克密理愽
  • merck millipore,默克密理博,05-654,Anti-Caspase 3 Antibody, clone 4-1-18

  • merck millipore,默克密理博,05-654,Anti-Caspase 3 Antibody, clone 4-1-18

    产品名称：Anti-Caspase 3 Antibody, clone 4-1-18
    产品型号：05-654
    Anti-Caspase 3 Antibody, clone 4-1-18 is an antibody against Caspase 3 for use in WB.

    merck millipore,默克密理博,05-654,Anti-Caspase 3 Antibody, clone 4-1-18

  • 产品介绍
  • merck millipore,默克密理博,05-654,Anti-Caspase 3 Antibody, clone 4-1-18

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-654
    Replaces 04-440; 04-1088
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-Caspase 3 Antibody, clone 4-1-18
    产品信息
    格式 Purified
    演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
    应用
    应用 Anti-Caspase 3 Antibody, clone 4-1-18 is an antibody against Caspase 3 for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 N-terminal HIS tagged fusion protein corresponding to full length human Caspase 3
    克隆 4-1-18
    宿主 Mouse
    特异性 full-length Caspase 3 and its subunit
    同种型 IgG2a
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_032991
    Entrez基因汇总 This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
    基因符号
    • Yama
    • CASP3
    • apopain
    • CASP-3
    • procaspase3
    • CPP32B
    • SCA-1
    • CPP-32
    • Apopain
    • CPP32
    纯化方法 Protein G chromatography
    UniProt编号
    • P42574
    UniProt汇总 FUNCTION: SwissProt: P42574 # Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp- -Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.
    SIZE: 277 amino acids; 31608 Da
    SUBUNIT: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 17 kDa (p17) and a 12 kDa (p12) subunit.
    SUBCELLULAR LOCATION: Cytoplasm.
    TISSUE SPECIFICITY: Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.
    PTM: Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits. Additional processing of the propeptides is likely due to the autocatalytic activity of the activated protease. Active heterodimers between the small subunit of caspase-7 protease and the large subunit of caspase-3 also occur and vice versa.
    SIMILARITY: SwissProt: P42574 ## Belongs to the peptidase C14 family.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on RIPA lysates from Jurkat cells
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C
    包装信息
    数量 100 µg

    merck millipore,默克密理博,05-654,Anti-Caspase 3 Antibody, clone 4-1-18

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