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品种反应性 主要应用 宿主 格式 抗体类型 H IHC, WB Rb Purified Polyclonal Antibody 描述 产品目录编号 06-478 品牌系列 Upstate
商名 - Upstate
描述 Anti-HSP27 Antibody 产品信息 格式 Purified 演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl with 0.05% sodium azide 应用 应用 Anti-HSP27 Antibody detects level of HSP27 & has been published & validated for use in WB, IH. 主要应用 - Immunohistochemistry
- Western Blotting
生物信息 免疫原品种 Recombinant human HSP27 宿主 Rabbit 特异性 HSP27 同种型 IgG 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_001540
基因符号 - SRP27
- HSPB1
- Hs.76067
- HSP27
- Hsp25
- HspB1
- HSP28
- CMT2F
- HS.76067
- DKFZp586P1322
- HMN2B
纯化方法 Protein A chromatography UniProt编号 - P04792
UniProt汇总 FUNCTION: SwissProt: P04792 # Involved in stress resistance and actin organization.
SIZE: 205 amino acids; 22783 Da SUBUNIT: Interacts with TGFB1I1 (By similarity). Associates with alpha- and beta-tubulin and microtubules. Interacts with HSPB8 and HSPBAP1.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock.
PTM: Phosphorylated in MCF-7 cells on exposure to protein kinase C activators and heat shock.
DISEASE: SwissProt: P04792 # Defects in HSPB1 are the cause of Charcot-Marie-Tooth disease type 2F (CMT2F) [MIM:606595]. CMT2F is a form of Charcot- Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT2 group are characterized by signs of axonal regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced. CMT2F onset is between 15 and 25 years with muscle weakness and atrophy usually beginning in feet and legs (peroneal distribution). Upper limb involvement occurs later. CMT2F inheritance is autosomal dominant. & Defects in HSPB1 are a cause of distal hereditary motor neuropathy (dHMN) [MIM:608634]. Distal HMN is a pure motor peripheral neuropathy without sensory abnormalities.
SIMILARITY: SwissProt: P04792 ## Belongs to the small heat shock protein (HSP20) family.产品使用声明 质量保证 routinely evaluated by immunoblot on cell lysates of heat shocked human MCF7 cells or in cell lysates of heat shocked human HeLa cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 250 µg
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下一件merck millipore产品：merck millipore,默克密理博,MAB8920,Anti-Measles Blend Antibody, hemagglutinin & matrix protein, clones CV1, CV4, CV8, CV9
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