• merck millipore,默克密理博,06-1359,Anti-acetyl-Histone H1 (Lys46) Antibody
  • merck millipore,默克密理博,06-1359,Anti-acetyl-Histone H1 (Lys46) Antibody

    产品名称:Anti-acetyl-Histone H1 (Lys46) Antibody
    产品型号:06-1359
    Use Anti-acetyl-Histone H1 (Lys46) Antibody (Rabbit Polyclonal Antibody) validated in WB, DB to detect acetyl-Histone H1 (Lys46) also known as Histone H1.4, Histone H1b, H1K46Ac.

    merck millipore,默克密理博,06-1359,Anti-acetyl-Histone H1 (Lys46) Antibody

  • 产品介绍
  • merck millipore,默克密理博,06-1359,Anti-acetyl-Histone H1 (Lys46) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    BWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 06-1359
    描述 Anti-acetyl-Histone H1 (Lys46) Antibody
    Alternate Names
    • Histone H1b
    • Histone H1.4
    背景信息 H1.4 is one of four variants of histone H1 (H1.2-H1.5) that is found in somatic cells. The H1 histones may function as linker proteins binding DNA via their GH domain, and enabling the wrapping of DNA around the core nucleosomal structure formed from the association of H2A, H2B, H3, and H4. In response to various stimuli, histones undergo a number of post-translational modifications (PTM) including acetylation, phoshorylation, and methylation. Previous studies have suggested that H1.4 may be phosphorylated during mitosis and interphase resulting in increased transcription of target genes by RNA polymerase I and II, and therefore this PTM on H1.4 may have implications for cell growth. H1.4 may also undergo acetylation of its N-terminal lysine residues. Often, it is the pattern of different modifications on several histone residues that alter chromatin and affect gene expression, rather than modification of single residues.
    产品信息
    格式 Affinity Purified
    控制
    • Calf thymus Histone H1 extract
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Use Anti-acetyl-Histone H1 (Lys46) Antibody (Rabbit Polyclonal Antibody) validated in WB, DB to detect acetyl-Histone H1 (Lys46) also known as Histone H1.4, Histone H1b, H1K46Ac.
    主要应用
    • Western Blotting
    应用说明 Dot Blot (Specificity) Analysis: A representative lot blocked acetyl-Histone H1 (Lys46) in unmodified and modified Histones. Possible cross-reactivity with core histones may be observed.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human Histone H1 acetylated at Lys46.
    表位 Acetylated Lys46
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes Histone H1 acetylated at Lys46.
    品种反应性 Bovine
    Species Reactivity Note Demonstrated to react with Bovine. Broad species reactivity expected based on sequence similarity.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_005312
    基因符号
    • H1F4
    • HIST1H1E
    修改
    • Acetylation
    纯化方法 Affinity purified
    UniProt编号
    • P10412
    产品使用声明
    质量保证 Evaluated by Western Blot in calf thymus Histone H1 extract.

    Western Blot Analysis: A 1:100 dilution of this antibody detected Histone H1 on 10 µg of calf thymus Histone H1 extract.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 200 µL

    merck millipore,默克密理博,06-1359,Anti-acetyl-Histone H1 (Lys46) Antibody

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