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merck millipore,默克密理博,06-1319,Anti-Histone H2A.Bbd Antibody
产品名称：Anti-Histone H2A.Bbd Antibody
产品型号：06-1319
Use Anti-Histone H2A.Bbd Antibody (Rabbit Polyclonal Antibody) validated in WB to detect Histone H2A.Bbd also known as H2A histone family member B1, H2A Barr body-deficient.
merck millipore,默克密理博,06-1319,Anti-Histone H2A.Bbd Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 06-1319 描述 Anti-Histone H2A.Bbd Antibody Alternate Names - histone H2A-Bbd type 1
- H2A histone family, member B1
- H2A Barr body-deficient
背景信息 Histone H2A.Bbd (Barr body-deficient), also known as histone H2A-Bbd type 1, is an atypical histone variant. This histone variant associates with H2B and replaces histone H2A in the nucleosome. In contrast to other H2A histones, this variant lacks conserved residues that are targets of post-translational modifications. Consequently this H2A.Bbd variant is about 15 amino acids shorter and only 48% similar to the canonical H2A. The major differences between the two are found in the docking domain that links H2A -H2B to the H3-H4 tetramer. Nucleosomes containing this histone adopt a more relaxed structure and protect ~118 base pairs of DNA instead of the 147 base pairs found in classical nucleosomes. This variant histone is associated with active X chromosomes and autosomes, and is typically absent from inactive X chromosomes. 产品信息 格式 Affinity Purified 控制 - Cell lysate overexpressing H2A.Bbd.
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Use Anti-Histone H2A.Bbd Antibody (Rabbit Polyclonal Antibody) validated in WB to detect Histone H2A.Bbd also known as H2A histone family member B1, H2A Barr body-deficient. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human Histone H2A.Bbd. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes Histone H2A.Bbd. 品种反应性 MouseHuman Species Reactivity Note Demonstrated to react with human and mouse.
抗体类型 Polyclonal Antibody Entrez基因编号 - NP_001017990
Entrez基因汇总 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. This gene is part of a region that is repeated three times on chromosome X, once in intron 22 of the F8 gene and twice closer to the Xq telomere. This record represents the most centromeric copy which is in intron 22 of the F8 gene. [provided by RefSeq]. 基因符号 - H2AFB1
- H2A.Bbd
纯化方法 Affinity purified UniProt编号 - P0C5Y9
UniProt汇总 FUNCTION: Atypical histone H2A which can replace conventional H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Nucleosomes containing this histone are less rigid and organize only 118 base pair of DNA instead of 147 in classical nucleosomes. They are associated with transcriptionally active chromatin and excluded form Barr bodies. Ref.4 Ref.5
SUBUNIT STRUCTURE: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. May be incorporated into a proportion of nucleosomes, replacing one or more H2A molecules.
SUBCELLULAR LOCATION: Nucleus. Chromosome. Note: Associated with the active X chromosome and with autosomes, while it is absent from the inactive X chromosome and excluded from Barr bodies.
DOMAIN: The docking domain is responsible for the weaker heterodimerization with H2B. Ref.4
MISCELLANEOUS: In contrast to other H2A histones, it does not contain the conserved residues that are the target of post-translational modifications.
SEQUENCE SIMILARITIES: Belongs to the histone H2A family.产品使用声明 质量保证 Evaluated by Western Blot using cell lysate overexpressing H2A.Bbd.
Western Blot Analysis: 0.5 µg/mL of this antibody detected Histone H2A.Bbd on 10 µg of recombinant histone proteins.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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