merck millipore,默克密理愽
  • merck millipore,默克密理博,05-673,Anti-phospho-Acetyl CoA Carboxylase (Ser79) Antibody, clone BK102

  • merck millipore,默克密理博,05-673,Anti-phospho-Acetyl CoA Carboxylase (Ser79) Antibody, clone BK102

    产品名称：Anti-phospho-Acetyl CoA Carboxylase (Ser79) Antibody, clone BK102
    产品型号：05-673
    Detect phospho-Acetyl CoA Carboxylase (Ser79) using this Anti-phospho-Acetyl CoA Carboxylase (Ser79) Antibody, clone BK102 validated for use in WB.

    merck millipore,默克密理博,05-673,Anti-phospho-Acetyl CoA Carboxylase (Ser79) Antibody, clone BK102

  • 产品介绍
  • merck millipore,默克密理博,05-673,Anti-phospho-Acetyl CoA Carboxylase (Ser79) Antibody, clone BK102

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, MWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-673
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-Acetyl CoA Carboxylase (Ser79) Antibody, clone BK102
    产品信息
    格式 Purified
    控制
    • Acid extracts of HeLa cells
    演示 Protein A Purified immunoglobulin in 0.1M Tris-Glycine, 0.15M NaCl and 0.05% sodium azide, pH 7.4.
    应用
    应用 Detect phospho-Acetyl CoA Carboxylase (Ser79) using this Anti-phospho-Acetyl CoA Carboxylase (Ser79) Antibody, clone BK102 validated for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 Synthetic peptide corresponding to rat Acetyl CoA Carboxylase
    克隆 BK102
    宿主 Mouse
    特异性 Recognizes phosphorylated Acetyl CoA Carboxylase (Ser79).
    同种型 IgG1λ
    品种反应性 RatMouse
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_198834, NM_001093
    Entrez基因汇总 Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.
    基因符号
    • ACAC
    • ACACA
    • ACC-alpha
    • ACCA
    • ACC
    • ACC1
    修改
    • Phosphorylation
    纯化方法 Protein G purfied
    UniProt编号
    • P11497
    UniProt汇总 FUNCTION: SwissProt: Q13085 # Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
    COFACTOR: Biotin. & Binds 2 manganese ions per subunit.
    SIZE: 2346 amino acids; 265554 Da
    SUBUNIT: Interacts in its inactive phosphorylated form with the BRCT domains of BRCA1 which prevents ACACA dephosphorylation and inhibits lipid synthesis.
    SUBCELLULAR LOCATION: Cytoplasm.
    TISSUE SPECIFICITY: Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver.
    PTM: Phosphorylation on Ser-1263 is required for interaction with BRCA1.
    SIMILARITY: SwissProt: Q13085 ## Contains 1 ATP-grasp domain. & Contains 1 biotin carboxylation domain. & Contains 1 biotinyl-binding domain. & Contains 1 carboxyltransferase domain.
    产品使用声明
    质量保证 Routinely evaluated by immunoblot on HeLa acid extracts
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 200 µg

    merck millipore,默克密理博,05-673,Anti-phospho-Acetyl CoA Carboxylase (Ser79) Antibody, clone BK102

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