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merck millipore,默克密理博,05-652,Anti-MUC1/episialin Antibody, clone 214D4
产品名称：Anti-MUC1/episialin Antibody, clone 214D4
产品型号：05-652
Anti-MUC1/episialin Antibody, clone 214D4 detects level of MUC1/episialin & has been published & validated for use in FC, IH.
merck millipore,默克密理博,05-652,Anti-MUC1/episialin Antibody, clone 214D4
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H IHC, FC M Purified Monoclonal Antibody 描述 产品目录编号 05-652 品牌系列 Upstate
商名 - Upstate
描述 Anti-MUC1/episialin Antibody, clone 214D4 Alternate Names - CD227
- Breast carcinoma-associated antigen DF3
- Carcinoma-associated mucin
- Episialin
- H23AG
- PEMT
- Peanut-reactive urinary mucin
- PUM
- Polymorphic epithelial mucin
- PEM
- Tumor-associated epithelial membrane antigen
- EMA
- Tumor-associated mucin
产品信息 格式 Purified 演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% 应用 应用 Anti-MUC1/episialin Antibody, clone 214D4 detects level of MUC1/episialin & has been published & validated for use in FC, IH. 主要应用 - Immunohistochemistry
- Flow Cytometry
生物信息 免疫原品种 Fusion protein, human b-gal-episialin/MUC1 repeat domain 克隆 clone 214D4 宿主 Mouse 特异性 MUC1/episialin 同种型 IgG1 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_182741
Entrez基因汇总 This gene is a member of the mucin family and encodes a membrane bound, glycosylated phosphoprotein. The protein is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type. It also includes a 20 aa variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length nature of only some has been determined. 基因符号 - CD227
- MUC1
- MUC1/ZD
- MUC-1/X
- PEMT
- MUC-1
- Episialin
- episialin
- MUC-1/SEC
- PUM
- EMA
- PEM
- H23AG
- MAM6
纯化方法 Protein G chromatography UniProt编号 - P15941
UniProt汇总 FUNCTION: SwissProt: P15941 # Isoform 7 behaves as a receptor and binds the secreted isoform 5. The binding induces the phosphorylation of the isoform 7, alters cellular morphology and initiates cell signaling. Can bind to GRB2 adapter protein.
SIZE: 1255 amino acids; 122072 Da
SUBUNIT: The cleaved form (only the isoform 1) of MUC1 forms a tight heterodimer with the released C-terminal peptide (which is first secreted to be extracellular).
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. & Isoform 5: Secreted. & Isoform 9: Secreted.
TISSUE SPECIFICITY: Expressed on ductal epithelial cells and on activated T-cells. Aberrantly glycosylated forms expressed in human epithelial tumors, such as breast or ovarian cancer and also in non-epithelial tumor cells. Isoform 7 expressed only in tumoral cells.
PTM: Highly glycosylated (N- and O-linked carbohydrates and sialic acid). In the 20 amino acid tandem repeat positions 5 (Ser), 6 (Thr), 14 (Thr), 15 (Ser) and 19 (Thr) are O-glycosylated (GalNAc). The average density of O-glycosylated sites within repeat peptides varies with cell differentiation from about 50% in lactation-associated MUC1 to over 90% in a variety of breast cancer cells. & Isoform 1 and isoform 7 undergoes transphosphorylation on serine and tyrosine residues.
SIMILARITY: SwissProt: P15941 ## Contains 1 SEA domain.产品使用声明 质量保证 routinely evaluated by immunohistochemistry 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
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