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merck millipore,默克密理博,05-545,Anti-PP2A Antibody, C subunit, clone 7A6
产品名称：Anti-PP2A Antibody, C subunit, clone 7A6
产品型号：05-545
Anti-PP2A Antibody, C subunit, clone 7A6 detects level of PP2A & has been published & validated for use in IP & WB.
merck millipore,默克密理博,05-545,Anti-PP2A Antibody, C subunit, clone 7A6
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Yeast (S. cerevisiae), H, M WB M Culture Supernatant Monoclonal Antibody 描述 产品目录编号 05-545 品牌系列 Upstate
商名 - Upstate
描述 Anti-PP2A Antibody, C subunit, clone 7A6 产品信息 格式 Culture Supernatant 控制 - Positive Control Included: Non-Stim A431 Cell Lysate (12-301)
演示 Cell culture supernatant containing 30% glycerol and 0.05% sodium azide as a preservative. 应用 应用 Anti-PP2A Antibody, C subunit, clone 7A6 detects level of PP2A & has been published & validated for use in IP & WB. 主要应用 - Western Blotting
生物信息 免疫原品种 peptide (C-bARRTPDYFL) corresponding to amino acids 302-309 of human PP2A catalytic subunit 克隆 7A6 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Recognizes the catalytic subunit of PP2A. 同种型 IgG 品种反应性 Yeast (S. cerevisiae)HumanMouse 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_004156
Entrez基因汇总 This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. 基因符号 - RP-C
- PPP2CA
- PP2CA
- PP2A-alpha
- PP2Ac
纯化方法 Unpurified UniProt编号 - P67775
UniProt汇总 FUNCTION: SwissProt: P67775 # PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Can dephosphorylate SV40 large T antigen and p53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but not C or ABC form is inhibited by small T antigen.
COFACTOR: Binds 1 iron ion per subunit (By similarity). & Binds 1 manganese ion per subunit (By similarity).
SIZE: 309 amino acids; 35594 Da
SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.
SUBCELLULAR LOCATION: Cytoplasm.
PTM: Reversibly methyl esterified on Leu-309. Carboxyl methylation may play a role in holoenzyme assembly. It varies during the cell cycle. & Phosphorylation of either threonine (by autophosphorylation- activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation.
SIMILARITY: SwissProt: P67775 ## Belongs to the PPP phosphatase family. PP-1 subfamily.产品使用声明 质量保证 routinely evaluated by immunoblot on RIPA lysates from A431 cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 包装信息 数量 200 µL
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