merck millipore,默克密理愽
  • merck millipore,默克密理博,05-469,Anti-p130 Cas Antibody, clone 8G4-E8

  • merck millipore,默克密理博,05-469,Anti-p130 Cas Antibody, clone 8G4-E8

    产品名称：Anti-p130 Cas Antibody, clone 8G4-E8
    产品型号：05-469
    Anti-p130 Cas Antibody, clone 8G4-E8 detects level of p130 Cas & has been published & validated for use in IP & WB.

    merck millipore,默克密理博,05-469,Anti-p130 Cas Antibody, clone 8G4-E8

  • 产品介绍
  • merck millipore,默克密理博,05-469,Anti-p130 Cas Antibody, clone 8G4-E8

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-469
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-p130 Cas Antibody, clone 8G4-E8
    Alternate Names
    • CRK-associated substrate
    • Breast cancer anti-estrogen resistance protein 1
    产品信息
    格式 Purified
    演示 0.1M Tris-glycine, pH7.0 and 0.05% sodium azide
    应用
    应用 Anti-p130 Cas Antibody, clone 8G4-E8 detects level of p130 Cas & has been published & validated for use in IP & WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 GST fusion to residues 670-896 of rat p130 Cas.
    克隆 8G4-E8
    宿主 Mouse
    特异性 p130 CAS
    同种型 IgG2a
    品种反应性 RatHumanMouse
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_014567
    基因符号
    • RBR-2
    • RBL2
    • Rb2
    • P130
    • PRB2
    • RB2
    • p130
    • FLJ26459
    纯化方法 Protein A chromatography
    UniProt编号
    • Q63767
    UniProt汇总 Function: Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. Implicated in induction of cell migration By similarity.
    Subunit structure: Forms complexes in vivo with focal adhesion kinase 1, adapter protein CRKL and LYN kinase. Can heterodimerize with CASL. Interacts with activated CSPG4. Interacts with BCAR3, NPHP1, PTK2B and SH2D3C. Interacts with INPPL1/SHIP2 By similarity.
    Subcellular location: Cell junction › focal adhesion. Cytoplasm. Note: Localizes at focal adhesions and stress fibers. Unphosphorylated form localizes in the cytoplasm and can move to the membrane upon tyrosine phosphorylation.
    Tissue specificity: Widely expressed. Higher expression in lung, intestine and testis.
    Domain: Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL SH2 domains. The HLH motif is absolutely required for the induction of pseudohyphal growth in yeast and mediates heterodimerization with CASL.
    A serine-rich region promotes activation of the serum response element (SRE).
    The SH3 domain is necessary for the localization of the protein to focal adhesions and interacts with one proline-rich region of focal adhesion kinase 1.
    Post-translational modification: Focal adhesion kinase 1 phosphorylates the protein at the YDYVHL motif. SRC-family kinases are recruited to the phosphorylated sites and can phosphorylate other tyrosine residues. Tyrosine phosphorylation is triggered by integrin mediated adhesion of cells to the extracellular matrix.
    Involvement in disease: Note=Appears to have a central function in transformation of some cell types.
    Sequence similarities: Belongs to the CAS family. Contains 1 SH3 domain.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on RIPA lysates from human A431, HFF, mouse 3T3 and rat L929 cells
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C
    包装信息
    数量 200 µg

    merck millipore,默克密理博,05-469,Anti-p130 Cas Antibody, clone 8G4-E8

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