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品种反应性 主要应用 宿主 格式 抗体类型 Rb, B, H, M, R WB M Purified Monoclonal Antibody 描述 产品目录编号 05-366 品牌系列 Upstate
商名 - Upstate
描述 Anti-PLCγ-1 Antibody, clone B-6-4 产品信息 格式 Purified 演示 Lyophilized powder 应用 应用 Anti-PLCγ-1 Antibody, clone B-6-4 is an antibody against PLCγ-1 for use in IP & WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Purified soluble phospholipase C (PLC) g-1 from bovine brain 克隆 clone B-6-4 宿主 Mouse 特异性 PLCγ-1; may also react with some non-PLC γ-1 SH-3 containing proteins 同种型 IgG 品种反应性 RabbitBovineHumanMouseRat 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_002660
Entrez基因汇总 The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. 基因符号 - inositoltrisphosphohydrolase
- PLCG1
- PLC1
- PLCgamma1
- PLC148
- PLC-II
- PLC-148
- 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate
- PLC-gamma-1
纯化方法 Protein G chromatography UniProt编号 - P19174
UniProt汇总 FUNCTION: SwissProt: P19174 # PLC-gamma is a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.
COFACTOR: Calcium.
SIZE: 1290 amino acids; 148532 Da
SUBUNIT: Interacts with CENTG1 via its SH3 domain (By similarity). Interacts with phosphorylated LAT upon TCR activation. Interacts with the Pro-rich domain of TNK1 via its SH3 domain. Associates with BLNK, VAV1, GRB2 and NCK1 in a B-cell antigen receptor- dependent fashion. Interacts with CBLB in activated T-cells; which inhibits phosphorylation. Interacts with SHB. Interacts via its SH3 domain with the Arg/Gly-rich-flanked Pro-rich domains of KHDRBS1/SAM68. This interaction is selectively regulated by arginine methylation of KHDRBS1/SAM68. Interacts with INPP5D/SHIP1 (By similarity).
PTM: The receptor-mediated activation of PLC-gamma-1 and PLC- gamma-2 involves their phosphorylation by tyrosine kinases in response to ligation of a variety of growth factor receptors and immune system receptors. & Ubiquitinated by CBLB in activated T-cells (By similarity).
SIMILARITY: SwissProt: P19174 ## Contains 1 C2 domain. & Contains 1 EF-hand domain. & Contains 2 PH domains. & Contains 1 PI-PLC X-box domain. & Contains 1 PI-PLC Y-box domain. & Contains 2 SH2 domains. & Contains 1 SH3 domain.产品使用声明 质量保证 routinely evaluated in immunoblot on acid precipitated protein from bovine brain, RIPA lysates from human A431cells, mouse 3T3/A31 fibroblasts or rat L6 myoblasts 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Lyophilized: 2 years at -20°C; Rehydrated: 6 months at -20°C 包装信息 数量 100 µg
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