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品种反应性 主要应用 宿主 格式 抗体类型 Rb, H, M, R IHC, WB M Purified Monoclonal Antibody 描述 产品目录编号 05-346 品牌系列 Upstate
商名 - Upstate
描述 Anti-MAP2 Antibody, clone 5F9 产品信息 格式 Purified 演示 200 µg of protein G purified mouse IgG1 in 200 µL of storage buffer (0.02 M phosphate buffer, pH 7.6, 0.25 M NaCl, and 0.1% sodium azide. Frozen at -20°C. 应用 应用 Detect MAP2 using this Anti-MAP2 Antibody, clone 5F9 validated for use in WB, IH. 主要应用 - Immunohistochemistry
- Western Blotting
生物信息 免疫原品种 Purified rat brain microtubules MAP2 克隆 clone 5F9 宿主 Mouse 特异性 MAP2 同种型 IgG1 品种反应性 RabbitHumanMouseRat 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_031847
Entrez基因汇总 The MAP2 gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. 基因符号 - MAP2B
- MAP2
- MAP2A
纯化方法 Protein G chromatography UniProt编号 - P11137
UniProt汇总 FUNCTION: SwissProt: P11137 # The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
SIZE: 1,827 amino acids (Isofoim 1; MAP2b); 471 amino acids (Isofoim 2; MAP2c); 1,823 amino acids (Isofoim 3; MAP2a); 559 amino acids (Isofoim 4; MAP2d);
SUBCELLULAR LOCATION: Cytoplasm. Cytoskeleton.
PTM: Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly. Isoform 2/MAP2c is probably phosphorylated by PKA at Ser-323, Ser-354 and Ser-386 and by FYN at Tyr-67.产品使用声明 质量保证 routinely evaluated on rat brain microsomal preparation (Catalog #12-144). 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
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