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merck millipore,默克密理博,05-1100X,Anti-Sulfotyrosine Antibody, Clone Sulfo-1C-A2
产品名称：Anti-Sulfotyrosine Antibody, Clone Sulfo-1C-A2
产品型号：05-1100X
Anti-Sulfotyrosine Antibody, Clone Sulfo-1C-A2 is a high quality Mouse Monoclonal Antibody for the detection of Sulfotyrosine & has been validated in WB, IP, ELISA.
merck millipore,默克密理博,05-1100X,Anti-Sulfotyrosine Antibody, Clone Sulfo-1C-A2
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 A ELISA, WB M Purified Monoclonal Antibody 描述 产品目录编号 05-1100X 品牌系列 Upstate
商名 - Upstate
描述 Anti-Sulfotyrosine Antibody, Clone Sulfo-1C-A2 背景信息 Sulfotyrosine is a common post-translational modification of secretory, plasma membrane, and lysosomal proteins. The sulfation reaction is catalyzed by specific sulfotransferase enzymes in the trans-Golgi-network. Tyrosine sulfation occurs in all multicellular organisms and up to 1% of the tyrosines in the total protein content of a cell can be sulfated. Sulfotyrosines mediates many receptor-ligand binding interactions, including the interaction of P-selectin glycoprotein ligand-1 with P-selectin, factor VIII binding to von Willebrand factor, and interactions between thrombin and hirudin. Sulfotyrosine is also involved in the entry of several parasites and viruses; for example, tyrosine sulfation of the HIV-1 co-receptor CCR5 is required for viral entry into host cells, and tyrosine sulfation of the Duffy antigen/receptor for chemokines is crucial for erythrocyte invasion by the malaria parasite Plasmodium vivax.
This clone was derived from the antibody described in Kehoe et al., 2006.产品信息 格式 Purified 演示 100 μl in 100 mM Tris, 150 mM NaCl, 180 mM Glycine, pH 7.5 containing 0.05% sodium azide. 应用 应用 Anti-Sulfotyrosine Antibody, Clone Sulfo-1C-A2 is a high quality Mouse Monoclonal Antibody for the detection of Sulfotyrosine & has been validated in WB, IP, ELISA. 主要应用 - ELISA
- Western Blotting
应用说明 WB, IP, ELISA 生物信息 免疫原品种 This antibody was developed using a phage display library as described in Kehoe et al., 2006. The selection antigens were KAKISDP-DY(SO3)MTGYMDAC and KDKKYATEY(SO3)-EYLDYDFC 表位 Sulfated Tyrosine 克隆 Sulfo-1C-A2 宿主 Mouse 特异性 Recognizes sulfated tyrosine residues on various proteins. Does not recognize phosphotyrosine or unmodified tyrosines. 同种型 IgG2aκ 品种反应性 All Species Reactivity Note Broad species reactivity. Tested using human, mouse, bovine, and porcine, but the antibody is predicted to recognize any sulfotyrosine, regardless of surrounding amino acid sequence. 抗体类型 Monoclonal Antibody 纯化方法 Culture supernatant, purified by protein G affinity chromatography 产品使用声明 质量保证 Assayed using sulfatase treated bovine fibrinogen vs. untreated fibrinogen. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year from date of receipt when stored at +2-8°C. 包装信息 数量 30 µL
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