merck millipore,默克密理博,04-452,Anti-TRAF6 (CT) Antibody, rabbit monoclonal

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merck millipore,默克密理博,04-452,Anti-TRAF6 (CT) Antibody, rabbit monoclonal
产品名称：Anti-TRAF6 (CT) Antibody, rabbit monoclonal
产品型号：04-452
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Anti-TRAF6 (C-term) Antibody, Rabbit detects level o More>>

merck millipore,默克密理博,04-452,Anti-TRAF6 (CT) Antibody, rabbit monoclonal

产品介绍

merck millipore,默克密理博,04-452,Anti-TRAF6 (CT) Antibody, rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
R, H, M	WB	Rb	Purified	Monoclonal Antibody

描述
产品目录编号	04-452
品牌系列	Upstate
商名	Upstate
描述	Anti-TRAF6 (CT) Antibody, rabbit monoclonal
背景信息	TNF receptor-associated factor 6 is a member of the TNF receptor associated factor (TRAF) protein family. TNF receptor-associated factor 6 proteins play an important role as adaptor protein for cell survival, proliferation, differentiation and stress responses. TNF receptor-associated factor 6 has unique binding behavior that result in signaling responses from the interleukin-1 receptor (IL-1R) toll-like receptor. TNF receptor-associated factor 6 mediates signaling indirectly with IL-1R/TLR through IRAK. This leads to activation of NF-κB and MAP kinase signaling pathways though downstream association with the TAB/TAK-1 complex. TNF receptor-associated factor 6 is also involved in the activation of Akt/PKB and serves as a direct E3 ligase which is essential for Akt ubiquitination.

产品信息
格式	Purified
演示	In 60% storage buffer (50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.

应用
应用	Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Anti-TRAF6 (C-term) Antibody, Rabbit detects level of TRAF6 (C-term) & has been published & validated for use in IF & WB.
主要应用	Western Blotting

生物信息
免疫原品种	KLH-conjugated synthetic peptide composed of residues at the C-terminus of human TRAF6.
宿主	Rabbit
特异性	Recognizes a region composed of residues at the C-terminus of human TRAF6.
同种型	IgG
品种反应性	RatHumanMouse
抗体类型	Monoclonal Antibody
Entrez基因编号	NM_145803.1 NM_004620.2
Entrez基因汇总	The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. Two alternatively spliced transcript variants encoding identical proteins have been reported.
基因符号	MGC:3310 TRAF6 RNF85
UniProt编号	Q9Y4K3
UniProt汇总	FUNCTION: SwissProt: Q9Y4K3 # Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Also involved in the IL-1 signaling pathway via MYD88 and IRAK kinases. Seems to be involved in IL-17 signaling (By similarity). Mediates activation of NF-kappa-B and JNK. May function as an E3 ubiquitin ligase. SIZE: 522 amino acids; 59573 Da SUBUNIT: Homotrimer (Probable). Binds to TNFRSF5/CD40 and TNFRSF11A/RANK. Associates with NGFR, TNFRSF17, IRAK1, IRAK2, IRAK3, IRAK4, RIPK2, MAP3K1, MAP3K5, MAP3K14, CSK, and TRAF- interacting protein TRIP and TRAF and TNF receptor associated protein TTRAP. Interacts with IL17R. Interacts with SQSTM1 bridging NTRK1 and NGFR. Forms a ternary complex with SQSTM1 and PRKCZ (By similarity). Interacts with PELI1, PELI2 and PELI3. Binds UBE2V1. Interacts with MAVS/IPS1. Interacts with TAX1BP1. Interacts with IL1RL1. Interacts with TRAFD1. Interacts with ZNF675. SUBCELLULAR LOCATION: Cytoplasm (Probable).TISSUE SPECIFICITY: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.DOMAIN:SwissProt: Q9Y4K3 The coiled coil domain mediates homo- and hetero- oligomerization. & The MATH/TRAF domain binds to receptor cytoplasmic domains. PTM: Polyubiquitinated (By similarity). SIMILARITY: Contains 1 MATH domain. & Contains 1 RING-type zinc finger. & Contains 2 TRAF-type zinc fingers.

产品使用声明
质量保证	Routinely evaluated by immunoblot.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.

储存和货运信息

存储条件

2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.