merck millipore,默克密理愽
  • merck millipore,默克密理博,04-385,Anti-mTOR Antibody, rabbit monoclonal

  • merck millipore,默克密理博,04-385,Anti-mTOR Antibody, rabbit monoclonal

    产品名称：Anti-mTOR Antibody, rabbit monoclonal
    产品型号：04-385
    Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. This Anti-mTOR Antibody is validated for use in FC,  More>>

    merck millipore,默克密理博,04-385,Anti-mTOR Antibody, rabbit monoclonal

  • 产品介绍
  • merck millipore,默克密理博,04-385,Anti-mTOR Antibody, rabbit monoclonal

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MWB, FC, ICCRbCulture SupernatantMonoclonal Antibody
    描述
    产品目录编号 04-385
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-mTOR Antibody, rabbit monoclonal
    Alternate Names
    • FRAP1, FRAP, FRAP2, RAFT1, RAPT1, FK506 binding protein 12-rapamycin associated protein 1
    • FRAP1
    • FRAP
    • FRAP2
    • RAFT1
    • RAPT1
    背景信息 mTOR (Mammalian Target of Rapamycin, aka FRAP, RAPT or RAFT) is a large 289 kDa Ser/Thr protein kinase that regulates cell cycle progression, cell growth, protein synthesis, ribosome biogenesis, and autophagy. mTOR is an evolutionarily conserved member of the Phosphoinositol Kinase-related Kinase (PIKK) family whose activity is regulated by phosphorylation on Ser2448 by Akt in response to insulin or muscle activity. Interestingly, mTOR is the central component of two multimeric kinase complexes consisting of mTOR and numerous other mTOR binding proteins. These two multimeric protein complexes are designated mTORC1 and mTORC2. mTORC1 (mTOR Complex 1) consists of at least mTOR, Raptor, and GL (mLST8). mTORC1 is known to play a central role in insulin signaling, which is crucial in maintaining metabolic homeostasis. The complex is activated primarily though the PI3 Kinase/Akt pathway. Upon insulin stimulation, Akt activates mTORC1 by phosphorylating and inhibiting TSC (and possibly other yet discovered targets and/or mTOR itself). This inhibits the upstream small GTPase regulator Rheb (Ras homolog enriched in brain). This inhibits the kinase activity of the mTORC1 complex, thus disabling its ability to phosphorylate its downstream targets such as p70 S6K on Thr389 and 4E-BP1 on Thr229. The other mTOR complex, mTORC2 (mTOR Complex 2), is made up of at least mTOR, Rictor, GL, Sin1, Protor 1 and 2. mTORC2 affects cell proliferation and survival primarily by phosphorylating the hydrophobic motif of Akt on Ser473, a well-known effecter of the PI3 Kinase pathway. In addition to phosphorylating Akt, the mTORC2 complex is also known to effect cytoskeletal organization and migration by exerting its effects through Rac, Rho, and PKC. Interestingly, unlike mTORC1, the mTORC2 complex appears to not be inhibited by treatment with rapamycin and for this reason is referred to as the rapamycin-insensitive complex. Defects in both mTOR complexes are associated with a variety of diseases, including cancer and diabetes.
    产品信息
    格式 Culture Supernatant
    演示 100 μL of rabbit monoclonal IgG in 60% storage buffer (50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.
    应用
    应用 Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. This Anti-mTOR Antibody is validated for use in FC, IC, IH(P), IP, WB for the detection of mTOR.
    主要应用
    • Western Blotting
    • Flow Cytometry
    • Immunocytochemistry
    生物信息
    免疫原品种 KLH-conjugated synthetic peptide corresponding to the C-terminal region of human mTOR.
    宿主 Rabbit
    特异性 Recognizes a region in the C-terminus domain of human mTOR.
    品种反应性 RatHumanMouse
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_004958.2
    Entrez基因汇总 The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The CDT6 gene is located in an intron of this gene.
    基因符号
    • RAFT1
    • FRAP1
    • RAPT1
    • MTOR
    • FRAP
    • mTOR
    • FLJ44809
    • FRAP2
    UniProt编号
    • P42345
    UniProt汇总 FUNCTION: SwissProt: P42345 # Acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Part of the TORC2 complex which plays a critical role in AKT1 Ser-473 phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization.
    SIZE: 2549 amino acids; 288892 Da
    SUBUNIT: Interacts with the FKBP12-rapamycin complex. Binds UBQLN1. Forms part of the mammalian target of rapamycin 2 complex (TORC2) comprised of FRAP1, GBL, PRR5, RICTOR and SIN. TORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to PRR5 and RICTOR within the TORC2 complex.
    TISSUE SPECIFICITY: Expressed in numerous tissues, with highest levels in testis.
    SIMILARITY: SwissProt: P42345 ## Belongs to the PI3/PI4-kinase family. & Contains 1 FAT domain. & Contains 1 FATC domain. & Contains 7 HEAT repeats. & Contains 1 PI3K/PI4K domain.
    产品使用声明
    质量保证 Routinely evaluated by immunoblot.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 2 years at -20°C from date of shipment.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,04-385,Anti-mTOR Antibody, rabbit monoclonal

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