merck millipore,默克密理愽
  • merck millipore,默克密理博,04-338,Anti-EGFR Antibody, rabbit monoclonal

  • merck millipore,默克密理博,04-338,Anti-EGFR Antibody, rabbit monoclonal

    产品名称：Anti-EGFR Antibody, rabbit monoclonal
    产品型号：04-338
    Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Anti-EGFR Antibody, rabbit detects level of EGFR & h More>>

    merck millipore,默克密理博,04-338,Anti-EGFR Antibody, rabbit monoclonal

  • 产品介绍
  • merck millipore,默克密理博,04-338,Anti-EGFR Antibody, rabbit monoclonal

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWB, FCRbPurifiedMonoclonal Antibody
    描述
    产品目录编号 04-338
    Replaces 04-337
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-EGFR Antibody, rabbit monoclonal
    Alternate Names
    • ERBB1
    • Epidermal growth factor receptor
    • ERBB
    产品信息
    格式 Purified
    控制
    • POSITIVE: A431 cells.
    演示 Rabbit monoclonal IgG in 30 mM Tris-Glycine (pH 7.4), 90 mM NaCl, 0.006% sodium azide, 0.03% BSA and 40% glycerol.
    应用
    应用 Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Anti-EGFR Antibody, rabbit detects level of EGFR & has been published & validated for use in FC, IF, IP & WB.
    主要应用
    • Western Blotting
    • Flow Cytometry
    应用说明 Western Blot: 1:10,000 on lysates from A431 cells.
    Immunoprecipitation: 1:30.
    Flow Cytometry: 1:10. Permeablization of cells required.
    Immunofluorescence: 1:50. Paraformaldehyde fixation recommended.

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 KLH-conjugated synthetic peptide corresponding to the C-terminal region of human EGF Receptor (EGFR).
    宿主 Rabbit
    特异性 Recognizes the C-terminal domain of EGFR and does not cross-react with any other ErbB family member.
    同种型 IgG
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_201284.1
    • NM_005228.3
    • NM_201282.1
    • NM_201283.1
    基因符号
    • mENA
    • EGFR
    • ERBB1
    • ERBB
    非反应性品种
    • Rat
    • Mouse
    UniProt编号
    • P00533
    UniProt汇总 FUNCTION: SwissProt: P00533 # Isoform 2/truncated isoform may act as an antagonist.
    SIZE: 1210 amino acids; 134277 Da
    SUBUNIT: Binds RIPK1. CBL interacts with the autophosphorylated C- terminal tail of the EGF receptor. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. The autophosphorylated form interacts with PIK3C2B, maybe indirectly. Interacts with PELP1.
    SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.
    TISSUE SPECIFICITY: Expressed in placenta. Isoform 2 is also expressed in ovarian cancers.
    PTM: Phosphorylation of Ser-695 is partial and occurs only if Thr- 693 is phosphorylated. & Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or signaling capacity but may play a role in lysosomal targeting. Polyubiquitin linkage is mainly through 'Lys-63', but linkage through 'Lys-48', 'Lys-11' and 'Lys-29' also occur.DISEASE:SwissProt: P00533 # Defects in EGFR are associated with lung cancer [MIM:211980].
    SIMILARITY: SwissProt: P00533 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. & Contains 1 protein kinase domain.
    MISCELLANEOUS: Binding of EGF to the receptor leads to dimerization, internalization of the EGF-receptor complex, induction of the tyrosine kinase activity, stimulation of cell DNA synthesis, and cell proliferation.
    产品使用声明
    质量保证 Routinely evaluated by immunoblot analysis.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C from date of shipment.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,04-338,Anti-EGFR Antibody, rabbit monoclonal

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