merck millipore,默克密理愽
  • merck millipore,默克密理博,04-334,Anti-phospho-Cbl (Tyr774) Antibody, rabbit monoclonal

  • merck millipore,默克密理博,04-334,Anti-phospho-Cbl (Tyr774) Antibody, rabbit monoclonal

    产品名称：Anti-phospho-Cbl (Tyr774) Antibody, rabbit monoclonal
    产品型号：04-334
    This Anti-phospho-Cbl (Tyr774) Antibody, rabbit is validated for use in FC, IF, IP, WB, IH(P) for the detection of phospho-Cbl (Tyr774).

    merck millipore,默克密理博,04-334,Anti-phospho-Cbl (Tyr774) Antibody, rabbit monoclonal

  • 产品介绍
  • merck millipore,默克密理博,04-334,Anti-phospho-Cbl (Tyr774) Antibody, rabbit monoclonal

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWB, FCRbPurifiedMonoclonal Antibody
    描述
    产品目录编号 04-334
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-Cbl (Tyr774) Antibody, rabbit monoclonal
    Alternate Names
    • Cas-Br-M (murine) ecotropic retroviral transforming sequence
    产品信息
    格式 Purified
    控制
    • POSITIVE: Pervanadate-treated Jurkat cells.
    演示 Rabbit monoclonal IgG in 30 mM Tris-Glycine (pH 7.4), 90 mM NaCl, 0.006% sodium azide, 0.03% BSA and 40% glycerol.
    应用
    应用 This Anti-phospho-Cbl (Tyr774) Antibody, rabbit is validated for use in FC, IF, IP, WB, IH(P) for the detection of phospho-Cbl (Tyr774).
    主要应用
    • Western Blotting
    • Flow Cytometry
    应用说明 Western Blot: 1:100 on lysates from pervanadate-treated Jurkat cells.
    Immunoprecipitation: 1:20.
    Flow Cytometry: 1:20. Permeablization of cells is required.
    Immunohistochemistry: 1:25 on paraffin-embedded sections of human cervical carcinoma.
    Immunofluorescence: 1:25. Paraformaldehyde fixation recommended.

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 KLH-conjugated synthetic peptide corresponding to the amino acid residues surrounding tyrosine 774 of human Cbl.
    宿主 Rabbit
    特异性 Recognizes Cbl when phosphorylated on tyrosine 774.
    同种型 IgG
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_005188.2
    Entrez基因汇总 The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation.
    基因符号
    • C-CBL
    • CBL
    • CBL2
    • RNF55
    修改
    • Phosphorylation
    非反应性品种
    • Rat
    • Mouse
    UniProt编号
    • P22681
    UniProt汇总 FUNCTION: SwissProt: P22681 # Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling.
    SIZE: 906 amino acids; 99647 Da
    SUBUNIT: Associates with NCK via its SH3 domain. The phosphorylated C-terminus interacts with CD2AP via its second SH3 domain. Binds to UBE2L3. Interacts with adapters SLA, SLA2 and with the phosphorylated C-terminus of SH2B2. Interacts with EGFR, SYK and ZAP70 via the highly conserved Cbl-N region. Also interacts with SORBS1 and INPPL1/SHIP2. Interacts with phosphorylated LAT2. May interact with CBLB (By similarity).
    SUBCELLULAR LOCATION: Cytoplasm.
    DOMAIN: SwissProt: P22681 The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme. & The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.
    PTM: Phosphorylated on tyrosine residues by EGFR, SYK, FYN and ZAP70 (By similarity). Phosphorylated on tyrosine residues by INSR.DISEASE:SwissProt: P22681 # Can be converted to an oncogenic protein by deletions or mutations that disturb its ability to down-regulate RTKs.
    SIMILARITY: Contains 1 CBL N-terminal domain. & Contains 2 EF-hand-like domains. & Contains 1 RING-type zinc finger. & Contains 1 SH2 domain. & Contains 1 UBA domain.
    MISCELLANEOUS: This protein has one functional calcium-binding site.
    产品使用声明
    质量保证 Routinely evaluated by immunoblot analysis.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C from date of shipment.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,04-334,Anti-phospho-Cbl (Tyr774) Antibody, rabbit monoclonal

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