merck millipore,默克密理博,04-323,Anti-AMPKα1 Antibody, rabbit monoclonal

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merck millipore,默克密理博,04-323,Anti-AMPKα1 Antibody, rabbit monoclonal
产品名称：Anti-AMPKα1 Antibody, rabbit monoclonal
产品型号：04-323
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Detect AMPKα1 using this Anti-AMPKα1 Antibody, Rabbi More>>

merck millipore,默克密理博,04-323,Anti-AMPKα1 Antibody, rabbit monoclonal

产品介绍

merck millipore,默克密理博,04-323,Anti-AMPKα1 Antibody, rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
R, H, M	WB	Rb	Purified	Monoclonal Antibody

描述
产品目录编号	04-323
品牌系列	Upstate
商名	Upstate
描述	Anti-AMPKα1 Antibody, rabbit monoclonal
Alternate Names	PRKAA1, protein kinase, AMP-activated, alpha 1 catalytic subunit, AMPK, AMPKa1, AMPK alpha 1 PRKAA1 protein kinase AMP-activated alpha 1 catalytic subunit AMPK AMPKa1

产品信息
格式	Purified
演示	In 60% storage buffer (50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.

应用
应用	Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Detect AMPKα1 using this Anti-AMPKα1 Antibody, Rabbit validated for use in IH(P), IP & WB.
主要应用	Western Blotting

生物信息
免疫原品种	KLH-conjugated synthetic peptide corresponding to the C-terminal region of human AMPKα1.
宿主	Rabbit
特异性	Recognizes the C-terminal domain of AMPKα1.
同种型	IgG
品种反应性	RatHumanMouse
抗体类型	Monoclonal Antibody
Entrez基因编号	NM_206907.3 NM_006251.5
Entrez基因汇总	The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
基因符号	AMPKa1 PRKAA1 MGC57364 AMPK AMPK1 MGC33776
UniProt编号	Q13131
UniProt汇总	FUNCTION: SwissProt: Q13131 # Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit. COFACTOR: Magnesium. SIZE: 550 amino acids; 62808 Da SUBUNIT: Heterotrimer of an alpha catalytic subunit, a beta and a gamma non-catalytic subunits. Interacts with FNIP1. SIMILARITY: SwissProt: Q13131 ## Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. & Contains 1 protein kinase domain.

产品使用声明
质量保证	Routinely evaluated by immunoblot.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.

储存和货运信息

存储条件

2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.