merck millipore,默克密理愽
  • merck millipore,默克密理博,04-1521,Anti-RPA1 p70 Antibody, clone RPA9, 1-30

  • merck millipore,默克密理博,04-1521,Anti-RPA1 p70 Antibody, clone RPA9, 1-30

    产品名称：Anti-RPA1 p70 Antibody, clone RPA9, 1-30
    产品型号：04-1521
    Use Anti-RPA1 p70 Antibody, clone RPA9, 1-30 (mouse monoclonal antibody) validated in WB, ICC to detect RPA1 p70 also known as RF-A protein 1, RP-A p70, Replication factor A protein 1, REPA1, RPA1, HS More>>

    merck millipore,默克密理博,04-1521,Anti-RPA1 p70 Antibody, clone RPA9, 1-30

  • 产品介绍
  • merck millipore,默克密理博,04-1521,Anti-RPA1 p70 Antibody, clone RPA9, 1-30

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HICC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 04-1521
    描述 Anti-RPA1 p70 Antibody, clone RPA9, 1-30
    Alternate Names
    • HSSB.
    • RF-A protein 1
    • RP-A p70
    • Replication factor A protein 1
    • Single-stranded DNA-binding protein
    • replication protein A 70 kDa DNA-binding subunit
    • replication protein A1 (70kD)
    • replication protein A1, 70kDa
    • REPA1
    • RPA1
    背景信息 Replication protein A (RPA) is a multisubunit complex involved in DNA mismatch repair (MMR) in association with MSH2, MLH1 , PCNA, and DNA polymerase-delta. RPA is a heterotrimer that includes subunits of 70 kDa (RPA1), 32kDa (RPA2), and 14kDa (RPA3). RPA1 p70 kDa is an ssDNA binding protein shown to be phosphorylated by ATM and ATR in response to DNA damage.RPA also functions in the initiation of DNA replication and DNA unwinding at origins of replication.
    产品信息
    格式 Purified
    控制
    • HeLa cell lysate
    演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
    应用
    应用 Use Anti-RPA1 p70 Antibody, clone RPA9, 1-30 (mouse monoclonal antibody) validated in WB, ICC to detect RPA1 p70 also known as RF-A protein 1, RP-A p70, Replication factor A protein 1, REPA1, RPA1, HSSB.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Immunocytochemistry
    Preformed by an external laboratory using representative lot of this antibody.
    生物信息
    免疫原品种 His-tagged recombinant protein corresponding to human RPA1.
    克隆 RPA9, 1-30
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 This antibody recognizes RPA1.
    同种型 IgG1κ
    品种反应性 Human
    Species Reactivity Note Proven to react with human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_002945
    基因符号
    • RPA70
    • RPA1
    • REPA1
    • RF-A
    • RP-A
    纯化方法 Protein G purfied
    UniProt编号
    • P27694
    UniProt汇总 FUNCTION: It participates in a very early step in initiation. RP-A is a single-stranded DNA-binding protein. Absolutely required for simian virus 40 DNA replication in vitro.

    SUBUNIT STRUCTURE: Heterotrimer of 70, 32 and 14 kDa chains. The DNA-binding activity may reside exclusively on the 70 kDa subunit. Interacts with RIP and XPA. Interacts with RPA4.

    SUBCELLULAR LOCATION: Nucleus.

    PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.

    SEQUENCE SIMILARITIES: Belongs to the replication factor A protein 1 family.
    产品使用声明
    质量保证 Evaluated by Western Blot in HeLa cell lysate.

    Western Blot Analysis: 1 µg/mL of this antibody detected RPA1 on 10 µg of HeLa cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,04-1521,Anti-RPA1 p70 Antibody, clone RPA9, 1-30

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