merck millipore,默克密理博,04-011,Anti-JAK3 Antibody, clone HL423, rabbit monoclonal

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merck millipore,默克密理博,04-011,Anti-JAK3 Antibody, clone HL423, rabbit monoclonal
产品名称：Anti-JAK3 Antibody, clone HL423, rabbit monoclonal
产品型号：04-011
Anti-JAK3 Antibody, clone HL423 is an antibody against JAK3 for use in Mplex & WB.

merck millipore,默克密理博,04-011,Anti-JAK3 Antibody, clone HL423, rabbit monoclonal

产品介绍

merck millipore,默克密理博,04-011,Anti-JAK3 Antibody, clone HL423, rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
M, H	WB	Rb	Culture Supernatant	Monoclonal Antibody

描述
产品目录编号	04-011
品牌系列	Upstate
商名	Upstate
描述	Anti-JAK3 Antibody, clone HL423, rabbit monoclonal
Alternate Names	JAK-3, Janus kinase 3, Tyrosine protein Kinase JAK3 JAK-3 Janus kinase 3

产品信息
格式	Culture Supernatant
演示	200 μL rabbit monoclonal hybridoma culture supernatant with 0.05% sodium azide.

应用
应用	Anti-JAK3 Antibody, clone HL423 is an antibody against JAK3 for use in Mplex & WB.
主要应用	Western Blotting

生物信息
免疫原品种	Inotek Corphis-tagged C-term of mouse JAK3 protein.
克隆	clone HL423
宿主	Rabbit
特异性	Recognizes JAK3, with some slight cross reaction with JAK1.
同种型	IgG
品种反应性	MouseHuman
抗体类型	Monoclonal Antibody
Entrez基因编号	NM_000215.2
Entrez基因汇总	JAK3 encodes Janus kinase 3, a tyrosine kinase that belongs to the Janus family. JAK3 functions in signal transduction and interacts with members of the STAT (signal transduction and activators of transcription) family. JAK3 is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations that abrogate Janus kinase 3 function cause an autosomal SCID (severe combined immunodeficiency disease).
基因符号	JAK3_HUMAN JAK3 LJAK L-JAK JAK-3 JAKL
纯化方法	Hybridoma culture supernatant
UniProt编号	P52333
UniProt汇总	FUNCTION: SwissProt: P52333 # Tyrosine kinase of the non-receptor type, involved in the interleukin-2 and interleukin-4 signaling pathway. Phosphorylates STAT6, IRS1, IRS2 and PI3K. SIZE: 1124 amino acids; 125099 Da SUBUNIT: Interacts with STAM2 and MYO18A (By similarity). Interacts with SHB. SUBCELLULAR LOCATION: Intracytoplasmic membrane; Peripheral membrane protein (By similarity). Note=Wholly intracellular, possibly membrane associated (By similarity). TISSUE SPECIFICITY: In NK cells and an NK-like cell line but not in resting T-cells or in other tissues. The S-form is more commonly seen in hematopoietic lines, whereas the B- and M-forms are detected in cells both of hematopoietic and epithelial origins. DOMAIN: SwissProt: P52333 Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1. PTM: Tyrosine phosphorylated in response to IL-2 and IL-4. DISEASE: SwissProt: P52333 # Defects in JAK3 are a cause of autosomal recessive T-cell negative/B-cell positive type of severe combined immunodeficiency (SCID) [MIM:600802]; a condition characterized by the absence of circulating mature T-lymphocytes and NK cells, normal to elevated numbers of nonfunctional B-lymphocytes, and marked hypoplasia of lymphoid tissues. SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. & Contains 1 FERM domain. & Contains 1 protein kinase domain. & Contains 1 SH2 domain.

产品使用声明
质量保证	Routinely evaluated by immunoblot.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/ thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/ thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.