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品种反应性 主要应用 宿主 格式 抗体类型 B WB M Purified Monoclonal Antibody 描述 产品目录编号 MABT109 描述 Anti-Aggrecan Antibody, clone 7D1 Alternate Names - CSPCP
- Aggrecan core protein
- Cartilage-specific proteoglycan core protein
背景信息 Aggrecan (CSPG1, CSPCP, or CSPGCP) is a chondroitin-sulfate proteoglycan belonging to the family of letican proteins. Aggrecan is a large globar structure containing multiple domains including carbohydrate-recognition domains; complement binding protein domains; immunoglobulin domains; proteoglycan tandem repeats; and in some cases, EGF-like domains. It can be degraded by aggrecanase. The N-terminus of aggrecan binds ECM hyaluronan in the presence of the linking protein, and forms complex aggregates, whereas the C-terminus binds a number of other ECM proteins including tenascins, glycolipids, and fibulins. Aggrecan is a major component of cartilage tissue and it enables this tissue to withstand compression by maintaining the viso-elastic properties of cartilage. Aggrecan may also facilitate neural maturation and plasticity by contributing to the formation of perineuronal nets in the developing CNS. 产品信息 格式 Purified 控制 - A1D1 purified protein from bovine tissue lysate.
演示 Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide. 应用 应用 Detect Aggrecan using this Anti-Aggrecan Antibody, clone 7D1 validated for use in Western Blotting. 主要应用 - Western Blotting
生物信息 免疫原品种 Other corresponding to A1D1-OH of rat chondrosarcoma aggrecan. 克隆 7-D-1 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgMκ 品种反应性 Bovine Species Reactivity Note Demonstrated to react with Bovine. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_071526
Entrez基因汇总 An extracellular matrix proteoglycan; cleaved by ADAMTS1. 基因符号 - Agc1
- Acan
- Agc
纯化方法 Purified by ion-exchange chromatography UniProt编号 - P07897
UniProt汇总 FUNCTION: This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.
SUBUNIT STRUCTURE: Interacts with FBLN1 and COMP.
SUBCELLULAR LOCATION: Secreted > extracellular space > extracellular matrix.
DOMAIN: Two globular domains, G1 and G2, comprise the N-terminus of the proteoglycan, while another globular region, G3, makes up the C-terminus. G1 contains Link domains and thus consists of three disulfide-bonded loop structures designated as the A, B, B' motifs. G2 is similar to G1. The keratan sulfate (KS) and the chondroitin sulfate (CS) attachment domains lie between G2 and G3.
POST-TRANSLATIONAL MODIFICATION: Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides.
SEQUENCE SIMILARITIES: Belongs to the aggrecan/versican proteoglycan family. Contains 1 C-type lectin domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain. Contains 4 Link domains. Contains 1 Sushi (CCP/SCR) domain.产品使用声明 质量保证 Evaluated by Western blot in A1D1 purified protein from bovine tissue lysate.
Western Blot Analysis: A 1:500 dilution from a representative lot detected A1D1 purified protein from bovine tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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