merck millipore,默克密理愽
  • merck millipore,默克密理博,MABT100,Anti-Girdin Antibody, CT, clone 10E6.1

  • merck millipore,默克密理博,MABT100,Anti-Girdin Antibody, CT, clone 10E6.1

    产品名称：Anti-Girdin Antibody, CT, clone 10E6.1
    产品型号：MABT100
    This Anti-Girdin, C-terminus Antibody, clone 10E6.1 is validated for use in Western Blotting, IHC(P), ICC, Immunoprecipitation for the detection of Girdin, C-terminus, clone 10E6.1.

    merck millipore,默克密理博,MABT100,Anti-Girdin Antibody, CT, clone 10E6.1

  • 产品介绍
  • merck millipore,默克密理博,MABT100,Anti-Girdin Antibody, CT, clone 10E6.1

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HICC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABT100
    描述 Anti-Girdin Antibody, CT, clone 10E6.1
    Alternate Names
    • HkRP1
    • Girdin
    • Akt phosphorylation enhancer
    • Coiled-coil domain-containing protein 88A
    • G alpha-interacting vesicle-associated protein
    • GIV
    • Girders of actin filament, Hook-related protein 1
    背景信息 Girdin (Ccdc88a; APE, GIV, or HkRP1) is a ubiquitous protein belonging to the CCDC88 family. Girdin is an actin-binding protein which interacts with actin via its C-terminal domain, and may play a crucial role in cell motility and cytoskeleton remodeling. These effects may be regulated by a reciprocal relationship between Girdin and Akt. Akt phosphorylates Girdin, and Girdin binds to Akt and enhances phosphorylation of Akt, thereby promoting phosphorylation of Akt’s downstream targets such as GSK-3β and FOXO1A. Girdin/Akt signaling may play an important role in cancer by facilitating the proliferation of cancer cells.
    产品信息
    格式 Purified
    控制
    • Human brain tissue lysate
    演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 This Anti-Girdin, C-terminus Antibody, clone 10E6.1 is validated for use in Western Blotting, IHC(P), ICC, Immunoprecipitation for the detection of Girdin, C-terminus, clone 10E6.1.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected Girdin in epithelial cells of human prostate tissue.

    Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected Girdin in HeLa cells.

    Immunoprecipitation Analysis: A representative lot immunoprecipitated Girdin in COS-7 cell lysate.
    生物信息
    免疫原品种 Recombinant protein corresponding to human Girdin.
    克隆 10E6.1
    宿主 Mouse
    同种型 IgG1κ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with Human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001129069
    Entrez基因汇总 This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
    基因符号
    • GRDN
    • CCDC88A
    • APE
    纯化方法 Protein G purified
    UniProt编号
    • Q3V6T2
    UniProt汇总 FUNCTION: Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation. Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome.

    SUBUNIT STRUCTURE: Interacts (via C-terminus) with DISC1; the interaction is direct. Interacts with AKT proteins; the interaction is inhibited in presence of DISC1. Homodimer. The non-phosphorylated form interacts with phosphatidylinositol 4-phosphate [PI4P] and weakly with phosphatidylinositol 3-phosphate [PI3P]. Interacts with microtubules. Interacts with actin through its C-terminal domain. Interacts with the C-terminus of AKT1/PKB.

    SUBCELLULAR LOCATION: Membrane. Cell membrane. Cytoplasm > cytosol. Cytoplasmic vesicle. Cell projection > lamellipodium. Note: Localizes to the cell membrane through interaction with phosphoinositides.

    TISSUE SPECIFICITY: Expressed ubiquitously.

    POST-TRANSLATIONAL MODIFICATION: Phosphorylation is induced by epidermal growth factor (EGF) in a phosphoinositide 3-kinase (PI3K)-dependent manner. Phosphorylation by AKT1/PKB is necessary for the delocalization from the cell membrane and for cell migration.

    SEQUENCE SIMILARITIES: Belongs to the CCDC88 family.

    SEQUENCE CAUTION: The sequence AAY14932.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAD97945.1 differs from that shown. Reason: Intron retention at the C-terminus. The sequence CAI46020.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    产品使用声明
    质量保证 Evaluated by Western Blot in human brain tissue lysate.

    Wesetern Blot Analysis: A 1:5000 dilution of this antibody detected Girdin in 10 µg of human brain tissue lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MABT100,Anti-Girdin Antibody, CT, clone 10E6.1

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