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品种反应性 主要应用 宿主 格式 抗体类型 H FC M Purified Monoclonal Antibody 描述 产品目录编号 MABS412 描述 Anti-EphA2 Antibody, clone SHM16 Alternate Names - Tyrosine-protein kinase receptor ECK
- Ephrin type-A receptor 2
- Epithelial cell kinase
背景信息 EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptor A2 (EphA2), also known as Eck, is a Receptor tyrosine kinase activated by the ligand ephrin-A1/EFNA1 that regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Additioanally, EphA2 regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. EphA2 may also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. Recent studies have shown that during development, EphA2 may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Additioanally, it interacts with ligand ephrin-A5/EFNA5 and may regulate lens fiber cells shape, lens transparency development and maintenance. EphA2 has been suggested to play in importnat role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis druing its interaction with ephrin-A2/EFNA2 . Mutations in EphA2 have been associated with Cataract 6, multiple types (CTRCT6): an opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. 产品信息 格式 Purified 演示 Purified mouse monoclonal IgG2bκ antibody in buffer containing PBS (pH 7.2) with up to 0.1% sodium azide. 应用 应用 Detect EphA2 using this mouse monoclonal antibody, Anti-EphA2 Antibody & clone SHM16 validated for use in Flow Cytometry. 主要应用 - Flow Cytometry
生物信息 免疫原品种 Immunogen information for this antibody is proprietary information. 克隆 SHM16 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgG2bκ 品种反应性 Human 抗体类型 Monoclonal Antibody 基因符号 - ECK
- EPHA2
纯化方法 Affinity UniProt编号 - P29317
产品使用声明 质量保证 Flow Cytometry Analysis: 1 μg of this antibody detected EphA2 in one million A375 cells. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 The antibody solution should be stored undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.
包装信息 数量 100 µg
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