- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H, R WB M Purified Monoclonal Antibody 描述 产品目录编号 MABS341 描述 Anti-LRP6 Antibody, clone 1C10 Alternate Names - LRP-6
- Low-density lipoprotein receptor-related protein 6
背景信息 Low density lipoprotein receptor-related protein 6, also known as LRP6, is a member of the low density Lipoprotein receptor gene family (LDLR). LDLR are cell surface proteins. LRP6 plays a crucial role in embryonic development by functioning as a co-receptor for the Wnt signaling pathway. LRP6 is highly homologous and presents itself as a dimer in the cell membrane until it is phosphlorylated by Wnt. LRP6 has a high affinity with the Dickkopf (DKK) family of antagonists which, when bound, block Wnt. When LRP6 binds to Wnt it is phosphlorated at multiple sites, which results in Axin, a scaffolding protein, being recruited to the cell membrane and β-catenin activation. β-catenin prevents Wnt and LRP6 from binding. LRP6 is associated with autosomal dominant coronary artery disease type 2. Mutations resulting in the omission of the extracellular domain of LPR6 results in constant activity whereas carboxy intracellular domain exclusion has a negative effect, resulting in the blocking of Wnt signaling. 产品信息 格式 Purified 控制 - HEK293 cell lysate
演示 Purified mouse monoclonal IgG containing PBS with 0.05% sodium azide. 应用 应用 This LRP6 antibody is validated for use in WB & IP for the detection of the LRP6 protein. 主要应用 - Western Blotting
应用说明 Immunoprecipitation Analysis: A representative lot immunoprecipitated LRP6 in certain cell lyates (Khan, Z., et al. (2007). Mol Cell Biol. 27(20):7291-7301.). 生物信息 免疫原品种 Flag-tagged recombinant protein corresponding to human LRP6. 克隆 1C10 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgG 品种反应性 MouseHumanRat Species Reactivity Note Demonstrated to react with Human, Rat, and Mouse. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_002327
基因符号 - LRP6
纯化方法 Protein G purified UniProt编号 - O75581
产品使用声明 质量保证 Evaluated by Western Blotting in HEK293 cell lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected LRP6 in 10 µg of HEK293 cell lysate. For enhanced results, it is recommended for end-users to perform higher dilutions of this antibody.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,AP162-KC,IgG, RB x CH (KC) - MG
下一件merck millipore产品：merck millipore,默克密理博,SF-1288,JAK1; Human, Cyanine 3 RNA Detection Probe,SmartFlare
相关产品
merck millipore,默克密理博,ACS510002,Amicon Pro Purification System with 100kDa Amicon Ultra-0.5 Device
merck millipore,默克密理博,ABT302,Anti-TRIM54 Antibody
merck millipore,默克密理博,353905,Glutathione Monoethyl Ester - CAS 118421-50-4 - Calbiochem
merck millipore,默克密理博,OP01A,Anti-v-H-Ras (Ab-1) Rat mAb (Y13-259) Agarose Conjugate
merck millipore,默克密理博,AP162-KC,IgG, RB x CH (KC) - MG
merck millipore,默克密理博,SF-1288,JAK1; Human, Cyanine 3 RNA Detection Probe,SmartFlare
merck millipore,默克密理博,14-531M,EGFR Protein, active, 250 µg
merck millipore,默克密理博,07-464,Anti-Vav3 Antibody, human
merck millipore,默克密理博,AB709-K,Goat Anti-Human IgM (mu chain) (1L)
merck millipore,默克密理博,MABN1041,Anti-TAB3 Antibody, clone EPR5965, rabbit monoclonal