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merck millipore,默克密理博,MABD19,Anti-DMP-1 (CT) Antibody, clone 8G10.3
产品名称：Anti-DMP-1 (CT) Antibody, clone 8G10.3
产品型号：MABD19
This Anti-DMP-1 (C-terminus) Antibody, clone 8G10.3 is validated for use in IH, DB for the detection of DMP-1 (C-terminus).
merck millipore,默克密理博,MABD19,Anti-DMP-1 (CT) Antibody, clone 8G10.3
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H, R IHC M Purified Monoclonal Antibody 描述 产品目录编号 MABD19 描述 Anti-DMP-1 (CT) Antibody, clone 8G10.3 Alternate Names - AG1
- Dentin matrix acidic phosphoprotein 1
- DMP-1
- Dentin matrix protein 1
背景信息 Dentin matrix protein 1, also known as DMP-1, is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in DMP-1 are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. 产品信息 格式 Purified 控制 - Human tooth sections
演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 This Anti-DMP-1 (C-terminus) Antibody, clone 8G10.3 is validated for use in IH, DB for the detection of DMP-1 (C-terminus). 主要应用 - Immunohistochemistry
应用说明 Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in rat mandibular sections. (Baba, O., et al. (2004). Matrix Biology. 23:371–379.)
Dot Blot Analysis: A representative lot was used by an independent laboratory in DB. (Baba, O., et al. (2004). Matrix Biology. 23:371–379.)生物信息 免疫原品种 57 kDa fragments isolated from rat bone 表位 C-terminus 克隆 8G10.3 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 This antibody detects the C-Terminus of DMP-1. 同种型 IgG1κ 品种反应性 MouseHumanRat Species Reactivity Note Demonstrated to react with Human. Predicted to react with Rat and Mouse based on 100% sequence homology. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_987089
Entrez基因汇总 Acidic protein associated with the dentin matrix; may be a matrix-associated acidic phosphoprotein; may have a regulatory role in dentin mineralization [RGD, Feb 2006]. 基因符号 - Dmp1
纯化方法 Protein G purified UniProt编号 - P98193
UniProt汇总 FUNCTION: May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite (By similarity).
SUBUNIT STRUCTURE: Interacts with importin alpha (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity). Secreted › extracellular space › extracellular matrix (By similarity). Note: In proliferating preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast localizes in the mineralizated matrix. Export from the nucleus of differentiating osteoblast is triggered by the release of calcium from intracellular stores followed by a massive influx of this pool of calcium into the nucleus (By similarity).
TISSUE SPECIFICITY: Expressed in tooth particularly in odontoblast and ameloblast.
PTM: Phosphorylated in the cytosol and extracellular matrix and unphosphorylated in the nucleus. Phosphorylation is necessary for nucleocytoplasmic transport and may be catalyzed by a nuclear isoform of CK2 and can be augmented by calcium (By similarity).产品使用声明 质量保证 Evaluated by Immunohistochemistry in human tooth sections.
Immunohistochemistry Analysis: 1:50-1:250 dilution of this antibody detected DMP-1 in human tooth sections.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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