merck millipore,默克密理博,MABC649,Anti-TSG101 Antibody, clone EPR7130(B), rabbit monoclonal

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merck millipore,默克密理博,MABC649,Anti-TSG101 Antibody, clone EPR7130(B), rabbit monoclonal
产品名称：Anti-TSG101 Antibody, clone EPR7130(B), rabbit monoclonal
产品型号：MABC649
Anti-TSG101 Antibody, clone EPR7130(B) is a rabbit monoclonal antibody, validated for use in western blotting & Flow Cytometry.

merck millipore,默克密理博,MABC649,Anti-TSG101 Antibody, clone EPR7130(B), rabbit monoclonal

产品介绍

merck millipore,默克密理博,MABC649,Anti-TSG101 Antibody, clone EPR7130(B), rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	FC, WB	Rb	Unpurified	Monoclonal Antibody

描述
产品目录编号	MABC649
描述	Anti-TSG101 Antibody, clone EPR7130(B), rabbit monoclonal
Alternate Names	ESCRT-I complex subunit TSG101 Tumor susceptibility gene 101 protein
背景信息	Tumor susceptibility gene 101 protein (TSG101), also known as ESCRT-I complex subunit TSG101, refers to a series of cytosolic protein complexes that are needed for the proper recognition and sorting of ubiquitin modified carrier proteins into the internal vesicles of the things like endosomes, and other multivesicular bodies (MVBs). TSG101 binds to the ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into MVBs. TSG101 also mediates the association between the ESCRT-0 and ESCRT-I complex in the passage of ubiquitin cargo proteins along the chain of ESCRTs. TSG101 interacts with a protein called stathmin, a cytoplasmic phosphoprotein that is implicated in tumorigenesis, and normal TSG101 appears to act as a negative regulator of growth, genetic stability and cell cycle regulation. Mutations and alternatively spliced mutants are associated with breast and other cancers suggesting that defects in TSG101 assist in tumorigenesis and progression. EMD-Millipore’s Anti-TSG101 rabbit monoclonal antibody has been tested in western blot on human brain lysates as well as cell lysates from K562, Jurkat, and SH-SY5Y human cell lines. The antibody has also been tested in flow cytometry on fixed, permeabilized K562 cells.

产品信息
格式	Unpurified
控制	Human brain tissue, K562, Jurkat, and SH-SY5Y cell lysates
演示	0

应用
应用	Anti-TSG101 Antibody, clone EPR7130(B) is a rabbit monoclonal antibody, validated for use in western blotting & Flow Cytometry.
主要应用	Flow Cytometry Western Blotting
应用说明	Flow Cytometry Analysis: A 1:10-100 dilution from a representative lot detected TSG101 in K562 cells. Optimal working dilutions must be determined by end user.

生物信息
免疫原品种	Synthetic peptide corresponding to human TSG101.
克隆	EPR7130(B)
宿主	Rabbit
品种反应性	Human
Species Reactivity Note	Demonstrated to react with Human.
抗体类型	Monoclonal Antibody
基因符号	TSG101
纯化方法	Unpurified
UniProt编号	Q99816

产品使用声明
质量保证	Evaluated by Western Blotting in human brain tissue, K562, Jurkat, and SH-SY5Y cell lysates. Western Blotting Analysis: A 1:1,000-10,000 dilution of this antibody detected TSG101 in human brain tissue, K562, Jurkat, and SH-SY5Y cell lysates.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.