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品种反应性 主要应用 宿主 格式 抗体类型 R, H, B, M ELISA, WB M Purified Monoclonal Antibody 描述 产品目录编号 MAB5586 Replaces AB5116 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Cyclooxygenase-1 Antibody 产品信息 格式 Purified 演示 Purified immunoglobulin. Liquid in 100 mM Tris, pH 7.5 with 0.05% sodium azide. 应用 应用 Anti-Cyclooxygenase-1 Antibody is an antibody against Cyclooxygenase-1 for use in WB, ELISA. 主要应用 - ELISA
- Western Blotting
应用说明 Western blot: 1:200-1:2,000 using ECL. The antibody reacts with the ~70 kDa protein in uninduced NIH/3T3 cells (2).
Immunohistochemistry: not tested. It is suggested that the antibody be tried at 5-10 μg/mL.
ELISA: 1,10,000-1:30,000.
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Purified Sheep Cox-1. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Cyclooxygenase 1 (Cox-1). 品种反应性 RatHumanBovineMouse 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_080591.1
- NM_000962.2
Entrez基因汇总 Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors. 基因符号 - EC 1.14.99.1
- PTGS1
- PCOX1
- PGHS1
- COX-1
- PGHS-1
- PGG/HS
- PHS1
- COX1
- PTGHS
- COX3
UniProt编号 - P23219
UniProt汇总 FUNCTION: SwissProt: P23219 # May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells.
COFACTOR: Binds 1 heme B (iron-protoporphyrin IX) group per subunit (By similarity).
SIZE: 599 amino acids; 68656 Da
SUBUNIT: Homodimer.
SUBCELLULAR LOCATION: Microsome membrane; Peripheral membrane protein.
SIMILARITY: SwissProt: P23219 ## Belongs to the prostaglandin G/H synthase family. & Contains 1 EGF-like domain.
MISCELLANEOUS: This enzyme acts both as a dioxygenase and as a peroxidase. & This enzyme is the target of nonsteroidal anti- inflammatory drugs such as aspirin.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 50 µg
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