merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB5356,Anti-Rhodopsin Antibody, CT, last 9 amino acids, clone Rho 1D4

  • merck millipore,默克密理博,MAB5356,Anti-Rhodopsin Antibody, CT, last 9 amino acids, clone Rho 1D4

    产品名称：Anti-Rhodopsin Antibody, CT, last 9 amino acids, clone Rho 1D4
    产品型号：MAB5356
    Anti-Rhodopsin Antibody, C-terminus, last 9 amino acids, clone Rho 1D4 detects level of Rhodopsin & has been published & validated for use in IC, IH, IP & WB.

    merck millipore,默克密理博,MAB5356,Anti-Rhodopsin Antibody, CT, last 9 amino acids, clone Rho 1D4

  • 产品介绍
  • merck millipore,默克密理博,MAB5356,Anti-Rhodopsin Antibody, CT, last 9 amino acids, clone Rho 1D4

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    VrtWB, ICC, IHCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB5356
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Rhodopsin Antibody, CT, last 9 amino acids, clone Rho 1D4
    产品信息
    格式 Purified
    控制
    • Eye
    演示 Protein A Purified mouse immunoglobulin in 20 mM sodium phosphate, 250 mM NaCl, pH. 7.6, with 0.1% sodium azide as a preservative.
    应用
    应用 Anti-Rhodopsin Antibody, C-terminus, last 9 amino acids, clone Rho 1D4 detects level of Rhodopsin & has been published & validated for use in IC, IH, IP & WB.
    主要应用
    • Western Blotting
    • Immunocytochemistry
    • Immunohistochemistry
    应用说明 Western blot: 1:100-1:500 using ECL. Suggested dilution buffer is PBS and blocking buffer is PBS containing 5% milk. Recognizes 36 kDa monomers, dimmers and trimers depending on sample preparation. Boiling induces the aggregation of rhodopsin.

    Western blot of isolated bovine rod outer segment labeled for rhodopsin (~85% of rod outer segment protein) with the rho 1D4 antibody. Amount of rod outer segments applied to the SDS gel: (a) 2.5 mg; (b) 0.63 mg; (c) 0.16 mg; (d) 0.04 mg. At higher protein quantities, dimers, trimers and tetramers of rhodopsin can be observed along with the monomer.

    Immunohisto/cytochemistry: 1:100-1:500 on paraformaldehyde and glutaraldehyde fixed frozen tissue sections. Preferred fixation is paraformaldehyde for 4 hours at 2-8°C. Suggested permeabilization method is 0.2% Triton X-100.

    Immunoprecipitation

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Bovine rhodopsin
    表位 C-terminus, last 9 amino acids
    克隆 Rho 1D4
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Recognizes Rhodopsin. Reacts with both native and recombinant protein. No known reactivity to other proteins.
    同种型 IgG1
    品种反应性 Vertebrates
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_000539.2
    Entrez基因汇总 Retinitis pigmentosa is an inherited progressive disease which is a major cause of blindness in western communities. It can be inherited as an autosomal dominant, autosomal recessive, or X-linked recessive disorder. In the autosomal dominant form,which comprises about 25% of total cases, approximately 30% of families have mutations in the gene encoding the rod photoreceptor-specific protein rhodopsin. This is the transmembrane protein which, when photoexcited, initiates the visual transduction cascade. Defects in this gene are also one of the causes of congenital stationary night blindness.
    基因符号
    • MGC138309
    • RHO
    • rhodopsin
    • Opsin-2
    • OPN2
    • Rhodopsin
    • RP4
    • MGC138311
    纯化方法 Protein A purfied
    UniProt编号
    • P08100
    UniProt汇总 FUNCTION: SwissProt: P08100 # Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal.
    SIZE: 348 amino acids; 38893 Da
    SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
    TISSUE SPECIFICITY: Rod shaped photoreceptor cells which mediates vision in dim light.
    PTM: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.
    DISEASE: SwissProt: P08100 # Defects in RHO are the cause of retinitis pigmentosa type 4 (RP4) [MIM:180380]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP4 inheritance is autosomal dominant. & Defects in RHO are a cause of retinitis pigmentosa autosomal recessive (ARRP) [MIM:268000]. & Defects in RHO are a cause of autosomal dominant congenital stationary night blindness 1 (CSNBAD1) [MIM:610445]; also known as rhodopsin-related congenital stationary night blindness. Congenital stationary night blindness is a nonprogressive retinal disorder characterized by impaired night vision and ocular symptoms such as myopia, hyperopia, nystagmus and reduced visual acuity.
    SIMILARITY: SwissProt: P08100 ## Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB5356,Anti-Rhodopsin Antibody, CT, last 9 amino acids, clone Rho 1D4

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