merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB388-100UG,Anti-Myelin Proteolipid Protein Antibody, CT, clone PLPC1

  • merck millipore,默克密理博,MAB388-100UG,Anti-Myelin Proteolipid Protein Antibody, CT, clone PLPC1

    产品名称：Anti-Myelin Proteolipid Protein Antibody, CT, clone PLPC1
    产品型号：MAB388-100UG
    Detect Myelin Proteolipid Protein using this Anti-Myelin Proteolipid Protein Antibody, C-terminus, clone PLPC1 validated for use in IH, IH(P) & WB.

    merck millipore,默克密理博,MAB388-100UG,Anti-Myelin Proteolipid Protein Antibody, CT, clone PLPC1

  • 产品介绍
  • merck millipore,默克密理博,MAB388-100UG,Anti-Myelin Proteolipid Protein Antibody, CT, clone PLPC1

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    MaWB, IHCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB388-100UG
    Replaces MAB388
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Myelin Proteolipid Protein Antibody, CT, clone PLPC1
    Alternate Names
    • PLP
    产品信息
    格式 Purified
    控制
    • Brain
    演示 Purified mouse immunoglobulin in PBS, pH 7.2 containing 0.09% sodium azide.
    应用
    应用 Detect Myelin Proteolipid Protein using this Anti-Myelin Proteolipid Protein Antibody, C-terminus, clone PLPC1 validated for use in IH, IH(P) & WB.
    主要应用
    • Western Blotting
    • Immunohistochemistry
    应用说明 Western Blotting: detects a 23-25kDa protein and DM20 a 20kDa protein; PLP can aggregate causing HMW bands to sometimes appear in certain preparations.

    Immunocytochemistry: 4% PFA fixed cells, 5-10 minutes room temperature. Use 0.1% triton in block only to allow antibody access to C-terminal epitope.

    Immunohistology on fresh frozen sections or 4% PFA fixed, frozen tissues. Epitope is internal, use 0.1-0.2% triton X-100 in the blocking step for permeabilization.

    Immunohistochemistry in paraffin: works best with lightly fixed tissues, or Bouin's fixed material, although there are reports of traditional formalin fixation also working with antigen recovery. {Mathis, et al 2003}.

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Myelin proteolipid protein, synthetic peptide CGRGTKF corresponding to the C-terminal peptide.
    表位 C-terminus
    克隆 PLPC1
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Reacts with myelin proteolipid protein in many mammalian species. Shows cross-reactivity to DM20.
    同种型 IgG2a
    品种反应性 Mammals
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_000533.3
    Entrez基因汇总 This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene.
    基因符号
    • PLP/DM20
    • PLP
    • PMD
    • MMP
    • SPG2
    纯化方法 Protein A purfied
    UniProt编号
    • P60201
    UniProt汇总 FUNCTION: SwissProt: P60201 # This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.
    SIZE: 277 amino acids; 30,077 Da
    SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
    PTM: Lipoprotein, Palmitate
    DISEASE:Defects in PLP1 are the cause of Pelizaeus-Merzbacher disease (PMD) [MIM:312080]. PMD is an X-linked neurologic disorder of myelin metabolism. It is characterized by early impairment of motor development (during the first three months of life) and, later, by the development of abnormal movements and progressive spastic paraplegia.
    SIMILARITY: Belongs to the myelin proteolipid protein family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB388-100UG,Anti-Myelin Proteolipid Protein Antibody, CT, clone PLPC1

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