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品种反应性 主要应用 宿主 格式 抗体类型 M, H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 07-1803 描述 Anti-TAF4 Antibody Alternate Names - TAFII135
- Transcription initiation factor TFIID subunit 4
- RNA polymerase II TBP-associated factor subunit C
- TBP-associated factor 4
- Transcription initiation factor TFIID 130 kDa subunit
- TAF(II)130
- TAFII-130
- TAFII130
- Transcription initiation factor TFIID 135 kDa subunit
- TAF(II)135
- TAFII-135
背景信息 TAF4 (TBP-associated factor 4) is necessary for modulation of transcriptional activity and for activating the retinoic acid receptor and CREB. TAF4 function is thought to be regulated by the alternative TAF4 isoforms. Co-localization of TAF4 and RanBPM has been found to be important in neuronal differentiation. TAF4 has also been associated with TFIID and is thought to be responsible for the TFIID complex stability. 产品信息 格式 Affinity Purified 控制 - HepG2 cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-TAF4 Antibody detects level of TAF4 & has been published & validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Linear Peptide corresponding to human TAF4. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 MouseHuman Species Reactivity Note Demonstrated to react with Human. Predicted to react with Mouse and Rat based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_003176
Entrez基因汇总 Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that has been shown to potentiate transcriptional activation by retinoic acid, thyroid hormone and vitamin D3 receptors. In addition, this subunit interacts with the transcription factor CREB, which has a glutamine-rich activation domain, and binds to other proteins containing glutamine-rich regions. Aberrant binding to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases. [provided by RefSeq]. 基因符号 - TAFII135
- TAF4
- TAF2C
- TAF2C1
- TAF4A
- TAFII130
纯化方法 Affinity purified UniProt编号 - O00268
UniProt汇总 FUNCTION: Makes part of TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone.
SUBUNIT STRUCTURE: TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H, TAF2, TAF4, TAF5, GCN5L2/GCN5, TAF10 and TRRAP. Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, IN80C, KIAA1267, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with ATF7; the interaction inhibits ATF7-mediated tranactivation. Interacts with SV40 Large T antigen.
SUBCELLULAR LOCATION: Nucleus.
SEQUENCE SIMILARITIES: Belongs to the TAF4 family.
Contains 1 TAFH (NHR1) domain.产品使用声明 质量保证 Evaluated by Western Blot in HepG2 cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected TAF4 on 10 µg of HepG2 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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