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品种反应性 主要应用 宿主 格式 抗体类型 Fe, B, Ch, Ht, M, R IHC, WB M Ascites Monoclonal Antibody 描述 产品目录编号 MAB366 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-MAP1B Antibody, clone AA6 Alternate Names - MAP5
产品信息 格式 Ascites 演示 Ascites. Liquid containing 15mM sodium azide. 应用 应用 Anti-MAP1B Antibody, clone AA6 detects level of MAP1B & has been published & validated for use in WB, IH. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunoblotting at 1:300-1:500.
Immunohistochemistry
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Rat brain microtubule-associated protein. 克隆 AA6 宿主 Mouse 特异性 Reacts specifically with MAP1B (MAP5) by immunoblot. Shows selective staining of dendritic trees throughout the brain. No cross-reactivity observed to other MAPs or tubulin.
Monoclonal Anti-MAP1b is immunospecific for MAP1b (also known as MAP5, MAPIX or MAP1.2; Riederer et al., 1986; Tucker et al., 1988) as determined by an immunoblot assay. Addition of antibody to microtubule proteins before polymerization results in abnormally short (but otherwise morphologically normal) microtubules.同种型 IgG1 品种反应性 FelineBovineChickenHamsterMouseRat 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_005909.3
- NM_032010.1
Entrez基因汇总 This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. 基因符号 - FLJ38954
- MAP1B
- DKFZp686F1345
- FUTSCH
- DKFZp686E1099
- MAP5
UniProt编号 - P46821
UniProt汇总 FUNCTION: SwissProt: P46821 # The function of brain MAPS is essentially unknown. Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B Binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules.
SIZE: 2468 amino acids; 270620 Da
SUBUNIT: 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. LC1 interacts with the amino- terminal region of MAP1B. Interacts with ANP32A (By similarity).
DOMAIN: SwissProt: P46821 Has a highly basic region with many copies of the sequence KKEE and KKEI/V, repeated but not at fixed intervals, which is responsible for the binding of MAP1B to microtubules.
PTM: LC1 is generated from MAP1B by proteolytic processing. & Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: Belongs to the MAP1 family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µL
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