merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB3317,Anti-MMP-14 Antibody, hemopexin domain, clone 113-5B7

  • merck millipore,默克密理博,MAB3317,Anti-MMP-14 Antibody, hemopexin domain, clone 113-5B7

    产品名称：Anti-MMP-14 Antibody, hemopexin domain, clone 113-5B7
    产品型号：MAB3317
    Anti-MMP-14 Antibody, hemopexin domain, clone 113-5B7 is an antibody against MMP-14 for use in ELISA, IH(P) & WB.

    merck millipore,默克密理博,MAB3317,Anti-MMP-14 Antibody, hemopexin domain, clone 113-5B7

  • 产品介绍
  • merck millipore,默克密理博,MAB3317,Anti-MMP-14 Antibody, hemopexin domain, clone 113-5B7

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, B, H, MWB, ELISAMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB3317
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-MMP-14 Antibody, hemopexin domain, clone 113-5B7
    Alternate Names
    • MT1-MMP
    产品信息
    格式 Purified
    控制
    • Breast carcinoma tissue
    演示 Purified immunoglobulin. Liquid in 0.1 M sodium phosphate buffer, pH 7.0, containing 2% protease-free bovine Serum albumin.
    应用
    应用 Anti-MMP-14 Antibody, hemopexin domain, clone 113-5B7 is an antibody against MMP-14 for use in ELISA, IH(P) & WB.
    主要应用
    • Western Blotting
    • ELISA
    应用说明 Western Blot: 10 μg/mL, membrane preparations; MD-MB-231 cells pretreated with 1-5 μg/mL ConA for 24-48 hours as positive control. 60-65 kDa proteins are identified.

    When tested against recombinant MT1-MMP (lacking the TM domain) expressed in CHO cells the antibody reacts with a band of ~59 kDa.

    Immunohistochemistry: Frozen tissue sections; traditional formalin fixation is problematic. Paraffin-embedded tissue sections with PLP fixation required.

    Immunoprecipitation

    EIA

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 CDGNFDTVAMLRGEM in the hemopexin-like domain of human MT1-MMP
    表位 a.a. 319-333
    克隆 113-5B7
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Reacts with human MMP-14, also known as MT1-MMP, with a very slight cross-reactivity to hMMP-3. For unknown reasons this antibody does not react on westerns to CC1043.
    同种型 IgG3κ
    品种反应性 RatBovineHumanMouse
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_004995.2
    Entrez基因汇总 Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.
    基因符号
    • EC 3.4.24.80
    • MMP14
    • MTMMP1
    • MMP-14
    • MT1MMP
    • MT1-MMP
    • MMP-X1
    纯化方法 Protein A purfied
    UniProt编号
    • P50281
    UniProt汇总 FUNCTION: SwissProt: P50281 # Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface.
    COFACTOR: Binds 1 zinc ion per subunit (By similarity). & Calcium (By similarity).
    SIZE: 582 amino acids; 65884 Da
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential). Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
    TISSUE SPECIFICITY: In stromal cells of colon, breast, and head and neck.
    DOMAIN: SwissProt: P50281 The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
    SIMILARITY: Belongs to the peptidase M10A family. & Contains 4 hemopexin-like domains.
    产品使用声明
    销售限制 This product is not available for sale in Japan.
    使用声明
    • Manufactured by Daiichi Fine Chemical Co., Ltd
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB3317,Anti-MMP-14 Antibody, hemopexin domain, clone 113-5B7

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