- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 07-1352 描述 Anti-acetyl STAT5B (Lys701) Antibody Alternate Names - Signal transducer and activator of transcription 5B
背景信息 STAT5B (signal transducers and activators of transcription 5b) controls the expression of early response genes and takes part in cytokine signaling. Studies have linked this protein to the inhibition of NFkappaB-mediated signaling. Additional studies have shown an association of STAT5B with regulation of lactation and growth, performance, and control of adipocyte function. Constitutively active STAT5B expression is often observed in a large number of leukemia’s and solid tumors. 产品信息 格式 Affinity Purified 控制 - Modified and non modified peptides of acetylated and non-acetylated STAT5B protein
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Detect acetyl STAT5B (Lys701) using this Anti-acetyl STAT5B (Lys701) Antibody validated for use in DB & WB. 主要应用 - Western Blotting
应用说明 Western Blot Analysis: A representative lot was used by an independent laboratory in WB. (Ma, L., et al. (2010). Proc Natl Acad Sci U S A. 107(45):19314-19319.) 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human STAT5B acetylated at Lys701. 表位 Acetylated Lys701 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes STAT5B acetylated at Lys701. 品种反应性 Human Species Reactivity Note Demonstrated to react with Human. Other homologies: Rat and Mouse (91% sequence homology). 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_036580
基因符号 - STAT5B
修改 - Acetylation
纯化方法 Affinity purified UniProt编号 - P51692
UniProt汇总 FUNCTION: Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.
SUBUNIT STRUCTURE: Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1, NMI and SOCS7.
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note: Translocated into the nucleus in response to phosphorylation (By similarity).
INVOLVEMENT IN DISEASE: Defects in STAT5B are the cause of Laron type dwarfism II (LTD2) [MIM:245590]; also known as Laron syndrome type II or Laron syndrome due to a post-receptor defect. The phenotypic features are consistent with growth hormone deficiency in the presence of normal to elevated circulating concentrations of growth hormone, and resistance to hexogeneous hormone therapy.
SEQUENCE SIMILARITIES: Belongs to the transcription factor STAT family.
Contains 1 SH2 domain.产品使用声明 质量保证 Evaluated by Dot Blot in modified and non modified peptides of acetylated and non-acetylated STAT5B protein.
Dot Blot Analysis: 1 µg/mL of this antibody detected STAT5B in modified and non modified peptides of acetylated and non-acetylated STAT5B protein.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,MAB80142,Anti-Norwalk Virus Antibody
下一件merck millipore产品：merck millipore,默克密理博,EZHPP40K,Human Pancreatic Polypeptide (PP) Elisa Kit
相关产品
merck millipore,默克密理博,MAB10754,Anti-Caspase-8 (active form p18 subunit) Antibody, clone 2B12.1
merck millipore,默克密理博,MAB5266,Anti-Neurofilament 200 kDa Antibody, clone N52
merck millipore,默克密理博,525290,PhosphoDetect™ Anti-Phosphotyrosine Rabbit pAb
merck millipore,默克密理博,07-651,Anti-SKAP-55 Antibody
merck millipore,默克密理博,MAB80142,Anti-Norwalk Virus Antibody
merck millipore,默克密理博,EZHPP40K,Human Pancreatic Polypeptide (PP) Elisa Kit
merck millipore,默克密理博,SF-1330,BCL9; Human, Cyanine 5 RNA Detection Probe,SmartFlare
%5BABN262_IHC(P)-ALL%5D.jpg "merck millipore,默克密理博,ABN262,Anti-Trypsin-3 Antibody")
merck millipore,默克密理博,ABN262,Anti-Trypsin-3 Antibody
merck millipore,默克密理博,MAB1564,Anti-Serotonin Transporter Antibody, clone 17-7A4
merck millipore,默克密理博,MAB3317,Anti-MMP-14 Antibody, hemopexin domain, clone 113-5B7