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merck millipore,默克密理博,MAB2259Z,Anti-Integrin β1 Antibody, activated, clone B44, azide free
产品名称：Anti-Integrin β1 Antibody, activated, clone B44, azide free
产品型号：MAB2259Z
This Anti-Integrin β1 Antibody, activated, clone B44, azide free is validated for use in FC, IH, IP, FUNC, CULT, WB for the detection of Integrin β1.
merck millipore,默克密理博,MAB2259Z,Anti-Integrin β1 Antibody, activated, clone B44, azide free
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB, FC, IHC, CULT M Purified Monoclonal Antibody 描述 产品目录编号 MAB2259Z 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Integrin β1 Antibody, activated, clone B44, azide free Alternate Names - MAB2259
- Ligand-inducedBindingSite
- LIBS
- CLIBS
产品信息 格式 Purified 控制 - Human lung, liver, and skeletal muscle tissues
演示 Purified immunoglobulin. Liquid PBS, containing no preservatives. 应用 应用 This Anti-Integrin β1 Antibody, activated, clone B44, azide free is validated for use in FC, IH, IP, FUNC, CULT, WB for the detection of Integrin β1. 主要应用 - Western Blotting
- Flow Cytometry
- Immunohistochemistry
- Cell Culture
应用说明 Immunoprecipitation of detergent-solubilized (1 integrins: 2-4 μg/IP
Western blot: 10-15 μg/mL
Flow Cytometry: 10-15 μg/mL
Immunohistochemistry
Stimulation of (1-mediated adhesion: 10-20 μg/mL.
Optimal working dilutions must be determined by end user.生物信息 表位 activated, azide free 克隆 B44 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Detects a cation- and ligand-induced binding site (LIBS) of integrin beta 1, which has been used in some systems as a reporter of integrin functionality. 同种型 IgG1 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_002292.3
基因符号 - LAMS
- LAMB2
- S-laminin
纯化方法 Protein A purfied UniProt编号 - P55268
UniProt汇总 FUNCTION: SwissProt: P55268 # Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
SIZE: 1798 amino acids; 195981 Da
SUBUNIT: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Beta-2 is a subunit of laminin-3 (S-laminin), laminin-4 (S- merosin), and laminin-7 (KS-laminin).
SUBCELLULAR LOCATION: Secreted, extracellular space. Note=S- laminin is concentrated in the synaptic cleft of the neuromuscular junction.
DOMAIN: SwissProt: P55268 The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure. & Domains VI and IV are globular.
DISEASE: SwissProt: P55268 # Defects in LAMB2 are the cause of Pierson syndrome [MIM:609049]; also known as microcoria-congenital nephrotic syndrome. Pierson syndrome is characterized by nephrotic syndrome with neonatal onset, diffuse mesangial sclerosis and eye abnormalities with microcoria as the leading clinical feature. Death usually occurs within the first weeks of life. Disease severity depends on the mutation type: nontruncating LAMB2 mutations may display variable phenotypes ranging from a milder variant of Pierson syndrome to isolated congenital nephrotic syndrome. & Defects in LAMB2 are a cause of congenital nephrotic syndrome [MIM:609049]. Congenital nephrotic syndrome constitutes a heterogeneous group of conditions having in common the disruption of normal glomerular permselectivity. Congenital nephrotic syndrome due to LAMB2 mutations may be associated with ocular abnormalities.
SIMILARITY: Contains 13 laminin EGF-like domains. & Contains 1 laminin IV type B domain. & Contains 1 laminin N-terminal domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 包装信息 数量 100 µg
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