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品种反应性 主要应用 宿主 格式 抗体类型 H IHC M Ascites Monoclonal Antibody 描述 产品目录编号 MAB1956 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Integrin α5 Antibody, clone P1D6 Alternate Names - CD49e
产品信息 格式 Ascites 控制 - Widely expressed, ovary
演示 UnPurified scites containing no preservatives. 应用 应用 Anti-Integrin α5 Antibody, clone P1D6 is an antibody against Integrin α5 for use in IH. 主要应用 - Immunohistochemistry
应用说明 MAB1956 is suitable for use in attachment inhibition assays using fibroblasts, endothelial cells, platelets and T & B lymphocytes on fibronectin.
MAB1956 is not reactive with the denatured alpha 5 subunit. For immunoblotting, a dot blot is suggested as an alternative to western blotting.生物信息 克隆 P1D6 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Reacts with Human alpha 5 integrin. Reactivity with other species is unknown. 同种型 IgG3 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_002205.2
Entrez基因汇总 The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. 基因符号 - FNRA
- ITGA5
- VLA-5
- CD49e
- VLA5A
纯化方法 Unpurified UniProt编号 - P08648
UniProt汇总 FUNCTION: SwissProt: P08648 # Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
SIZE: 1049 amino acids; 114536 Da
SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5. Interacts with HIV-1 Tat.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
SIMILARITY: SwissProt: P08648 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 包装信息 数量 100 µL
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