merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB1876,Anti-Integrin αVβ3 Antibody, clone 27.1 (VNR-1)

  • merck millipore,默克密理博,MAB1876,Anti-Integrin αVβ3 Antibody, clone 27.1 (VNR-1)

    产品名称：Anti-Integrin αVβ3 Antibody, clone 27.1 (VNR-1)
    产品型号：MAB1876
    Anti-Integrin αVβ3 Antibody, clone 27.1 (VNR-1) detects level of Integrin αVβ3 & has been published & validated for use in IF & IP.

    merck millipore,默克密理博,MAB1876,Anti-Integrin αVβ3 Antibody, clone 27.1 (VNR-1)

  • 产品介绍
  • merck millipore,默克密理博,MAB1876,Anti-Integrin αVβ3 Antibody, clone 27.1 (VNR-1)

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HFUNC, IF, IPMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB1876
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Integrin αVβ3 Antibody, clone 27.1 (VNR-1)
    Alternate Names
    • VNR-1
    • CD51/CD61
    产品信息
    格式 Purified
    演示 Protein A purified mouse immunoglobulin in liquid in 0.02M PB, pH 7.6, 0.25M NaCl containing 0.1% sodium azide.
    应用
    应用 Anti-Integrin αVβ3 Antibody, clone 27.1 (VNR-1) detects level of Integrin αVβ3 & has been published & validated for use in IF & IP.
    主要应用
    • Affects Function
    • Immunofluorescence
    • Immunoprecipitation
    应用说明 Immunohistochemistry: 4-10% formalin fixed frozen tissues (short fixation times, 10 minutes room temperature) only; not effective on paraffin embedded tissues

    Immunoprecipitation

    Functional blocking: Competes with clone LM609 for integrin function blocking.



    Optimal working dilutions must be determined by end user.
    生物信息
    克隆 27.1 (VNR-1)
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Reacts with the human integrin alphaVbeta3. Shown to be specific for alphaVbeta3 by Loftus JC et al (1990) Science 249:915-918.
    同种型 IgG1
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_002210.2
    Entrez基因汇总 ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction.
    基因符号
    • VNRA
    • ITGAV
    • DKFZp686A08142
    • MSK8
    • CD51
    UniProt编号
    • P06756
    UniProt汇总 FUNCTION: SwissProt: P06756 # The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and von Willebrand factor. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
    SIZE: 1048 amino acids; 116038 Da
    SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8 subunit. Interacts with HIV-1 Tat.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    SIMILARITY: SwissProt: P06756 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted aliquots for up to 12 months from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB1876,Anti-Integrin αVβ3 Antibody, clone 27.1 (VNR-1)

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