merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB1590,Anti-Na+/Ca++ Exchanger Antibody, clone 6H2

  • merck millipore,默克密理博,MAB1590,Anti-Na+/Ca++ Exchanger Antibody, clone 6H2

    产品名称：Anti-Na+/Ca++ Exchanger Antibody, clone 6H2
    产品型号：MAB1590
    This Anti-Na+/Ca++ Exchanger Antibody, clone 6H2 is validated for use in ELISA, IC, IH, IP, WB for the detection of Na+/Ca++ Exchanger.

    merck millipore,默克密理博,MAB1590,Anti-Na+/Ca++ Exchanger Antibody, clone 6H2

  • 产品介绍
  • merck millipore,默克密理博,MAB1590,Anti-Na+/Ca++ Exchanger Antibody, clone 6H2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Rb, M, Mk, RWB, ELISA, ICC, IHCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB1590
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Na+/Ca++ Exchanger Antibody, clone 6H2
    产品信息
    格式 Purified
    演示 Purified immunoglobulin from culture supernatant. Lyophilized from 5 mM ammonium biocarbonate. Contains no preservative. Reconstitute with 50 μL of PBS.
    应用
    应用 This Anti-Na+/Ca++ Exchanger Antibody, clone 6H2 is validated for use in ELISA, IC, IH, IP, WB for the detection of Na+/Ca++ Exchanger.
    主要应用
    • Western Blotting
    • ELISA
    • Immunocytochemistry
    • Immunohistochemistry
    应用说明 Western blot: 1:100-1:1000 (35S-protein A); Higher working dilutions may be necessary using ECL.

    Immunohisto/cytochemistry: 1:200-1:1000

    Immunoprecipitation

    ELISA

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Fusion protein from rabbit renal Na+/Ca++ Exchanger.
    克隆 6H2
    宿主 Mouse
    特异性 Strong and specific immunolabeling of 160 and 120 kD Na+/Ca++ Exchanger (NCX1) proteins in Western blot. In some preparations a 70kDa band breakdown fragment can also be observed.

    Membrane preparations are recommend that contain proteinase inhibitors.
    同种型 IgG2b
    品种反应性 RabbitMouseMonkeyRat
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_021097.2
    Entrez基因汇总 In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM]
    基因符号
    • MGC119581
    • SLC8A1
    • CNC
    • NCX1
    • Na
    • DKFZp779F0871
    • +Ca
    UniProt编号
    • P32418
    UniProt汇总 FUNCTION: SwissProt: P32418 # Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores.
    SIZE: 973 amino acids; 108547 Da
    SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
    TISSUE SPECIFICITY: Cardiac sarcolemma.
    SIMILARITY: SwissProt: P32418 ## Belongs to the sodium/potassium/calcium exchanger family. SLC8 subfamily. & Contains 2 Calx-beta domains.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain lyophilized material at -20°C for up to six months after receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to six months. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB1590,Anti-Na+/Ca++ Exchanger Antibody, clone 6H2

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