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merck millipore,默克密理博,GF128,Stromal Cell-Derived Factor-1α Protein, Recombinant mouse
产品名称：Stromal Cell-Derived Factor-1α Protein, Recombinant mouse
产品型号：GF128
Stromal Cell-Derived Factor-1 alpha protein (or SDF-1 alpha protein) is a recently discovered protein belonging to the alpha chemokine (CXC) family of cytokines.
merck millipore,默克密理博,GF128,Stromal Cell-Derived Factor-1α Protein, Recombinant mouse
- 产品介绍
重要规格表
主要应用 品种 来源 纯度 CULT Mouse E.coli Greater than 99% by SDS-PAGE and HPLC analysis. Endotoxin level is less than 0.1 ng per μg (1EU/ug) of SDF-1 alpha. 描述 产品目录编号 GF128 品牌系列 Chemicon®
商名 - Chemicon
描述 Stromal Cell-Derived Factor-1α Protein, Recombinant mouse 概述 Stromal Cell-Derived Factor-1 alpha (SDF-1 alpha) is a recently discovered protein belonging to the alpha chemokine (CXC) family of cytokines. Recombinant Mouse SDF-1 alpha is a 7.9 kDa protein containing 68 amino acid residues. Alternate Names - SDF-1alpha
产品信息 演示 The sterile filtered solution was lyophilized with no additives. 应用 应用 Stromal Cell-Derived Factor-1 alpha protein (or SDF-1 alpha protein) is a recently discovered protein belonging to the alpha chemokine (CXC) family of cytokines. 主要应用 - Cell Culture
生物信息 纯度 Greater than 99% by SDS-PAGE and HPLC analysis. Endotoxin level is less than 0.1 ng per μg (1EU/ug) of SDF-1 alpha. 来源 E.coli 品种 Mouse 特异活性 Determined by its ability to chemoattract human peripheral blood monocytes using a concentration of 50-100ng/ml. Entrez基因汇总 For background information on chemokines, see CXCL11 (SCYB11; MIM 604852). Stromal cell-derived factors 1-alpha and 1-beta are small cytokines that belong to the intercrine family, members of which activate leukocytes and are often induced by proinflammatory stimuli such as lipopolysaccharide, TNF (see MIM 191160), or IL1 (see MIM 147760). The intercrines are characterized by the presence of 4 conserved cysteines which form 2 disulfide bonds. They can be classified into 2 subfamilies. In the CC subfamily, which includes beta chemokine, the cysteine residues are adjacent to each other. In the CXC subfamily, which includes alpha chemokine, they are separated by an intervening amino acid. The SDF1 proteins belong to the latter group.[supplied by OMIM] UniProt编号 - P40224
- P48061
UniProt汇总 FUNCTION: SwissProt: P48061 # Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites.
SIZE: 93 amino acids; 10666 Da
SUBCELLULAR LOCATION: Secreted.
PTM: Processed forms SDF-1-beta(3-72) and SDF-1-alpha(3-67) are produced after secretion by proteolytic cleavage of isoforms Beta and Alpha, respectively. The N-terminal processing is probably achieved by DPP4. Isoform Alpha is first cleaved at the C-terminus to yield a SDF-1-alpha(1-67) intermediate before being processsed at the N-terminus. The C-terminal processing of isoform Alpha is reduced by binding to heparin and, probably, cell surface proteoglycans.
SIMILARITY: SwissProt: P48061 ## Belongs to the intercrine alpha (chemokine CxC) family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 The lyophilized powder is stable for a few weeks at room temperature, but best stored at -20°C. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or -20°C for future use. Reconstituted mouse SDF-1 alpha should be stored in undiluted aliquots at -20°C. Avoid repeated freeze/thaw cycles. 包装信息 数量 10 µg
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