merck millipore,默克密理愽
  • merck millipore,默克密理博,GF050,Leptin, mouse

  • merck millipore,默克密理博,GF050,Leptin, mouse

    产品名称：Leptin, mouse
    产品型号：GF050
    Leptin (Anti-Obesity Protein) is the protein product of the ob (obese) gene in mice & appears to be involved in appetite control.

    merck millipore,默克密理博,GF050,Leptin, mouse

  • 产品介绍
  • merck millipore,默克密理博,GF050,Leptin, mouse

    重要规格表

    主要应用 品种 来源 纯度
    CULTMouseE.coliGreater than 95% by SDS-PAGE and HPLC analyses
    描述
    产品目录编号 GF050
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Leptin, mouse
    概述 Leptin (Anti-Obesity Protein) is the protein product of the ob (obese) gene in mice and appears to be involved in appetite control. The ob gene is expressed in adipose tissue and is thought to regulate the body's fat stores. Mice with the ob/ob genotype also develop a form of diabetes similar to type II (non-insulin dependent) diabetes. Mouse leptin is a 16 kDa protein containing 147 amino acid residues.
    产品信息
    演示 Lyophilized from 0.1% TFA, no preservatives.
    应用
    应用 Leptin (Anti-Obesity Protein) is the protein product of the ob (obese) gene in mice & appears to be involved in appetite control.
    主要应用
    • Cell Culture
    生物信息
    纯度 Greater than 95% by SDS-PAGE and HPLC analyses
    来源 E.coli
    品种 Mouse
    特异活性 GF050 has been shown to be biologically active in two different mouse obesity models, ob/ob and NZO. Both strains of mice were treated via intraperitoneal injection once daily at a dose of 5 μg leptin/gm of body weight for 14 days. Significant effects on body weight, food consumption, and plasma glucose levels were observed compared to saline-treated controls.
    Entrez基因汇总 This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.
    UniProt编号
    • P41160
    • P41159
    UniProt汇总 FUNCTION: SwissProt: P41159 # May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.
    SIZE: 167 amino acids; 18641 Da
    SUBUNIT: Interacts with SIGLEC6.
    SUBCELLULAR LOCATION: Secreted.
    DISEASE:SwissProt: P41159 # Defects in LEP may be a cause of autosomal recessive obesity [MIM:601665].
    SIMILARITY: SwissProt: P41159 ## Belongs to the leptin family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 The lyophilized powder, though stable at room temperature, is best stored desiccated below 0°C for up to 12 months from date of receipt. After a quick spin, reconstitute the mouse leptin in sterile distilled water to a concentration of 1.0-5.0 mg/mL. After reconstitution maintain at -20°C in undiluted aliquots for up to six months.
    包装信息
    数量 1 mg

    merck millipore,默克密理博,GF050,Leptin, mouse

上一件merck millipore产品：merck millipore,默克密理博,14-645,IRR Protein, active, 10 µg
下一件merck millipore产品：merck millipore,默克密理博,4000-0041,Guava ViaCount Reagent for Flow Cytometry, 600 tests


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