merck millipore,默克密理博,GF038,Flt-3 Ligand Protein, Recombinant human

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merck millipore,默克密理博,GF038,Flt-3 Ligand Protein, Recombinant human
产品名称：Flt-3 Ligand Protein, Recombinant human
产品型号：GF038
The Flt3-ligand (flk2-ligand) stimulates the proliferation & colony formation of certain BM precursor cells including CD34+ cells.

merck millipore,默克密理博,GF038,Flt-3 Ligand Protein, Recombinant human

产品介绍

merck millipore,默克密理博,GF038,Flt-3 Ligand Protein, Recombinant human

重要规格表

主要应用	品种	来源	纯度
CULT	Human	E.coli	Greater than 98% by SDS-PAGE and HPLC analyses

描述
产品目录编号	GF038
品牌系列	Chemicon®
商名	Chemicon
描述	Flt-3 Ligand Protein, Recombinant human
概述	Flt3-ligand (flk2-ligand) stimulates the proliferation and colony formation of certain BM precursor cells including CD34+ cells. Chemicon's Human flt3-ligand is a soluble 17.6 kDa polypeptide containing 155 amino acid residues which comprises the extracellular domain of the transmembrane flt3-ligand protein.

产品信息
演示	Lyophilized protein with no additives. The protein may appear as a haze or film, which is difficult to see at the bottom of the vial.

应用
应用	The Flt3-ligand (flk2-ligand) stimulates the proliferation & colony formation of certain BM precursor cells including CD34+ cells.
主要应用	Cell Culture

生物信息
纯度	Greater than 98% by SDS-PAGE and HPLC analyses
来源	E.coli
品种	Human
特异活性	GF038 is fully biologically active when compared to standards. The ED(50) was determined by the dose-dependent stimulation of human AML5 cells is <= 1.0 ng/mL, corresponding to a specific activity of >= 1 x 10(E6) units/mg.
Entrez基因编号	NM_004119.2
Entrez基因汇总	This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
基因符号	EC 2.7.10.1 FLT3 STK-1 FLK2 CD135 OTTHUMP00000042340 STK1
UniProt编号	P36888
UniProt汇总	FUNCTION: SwissProt: P36888 # Receptor for the FL cytokine. Has a tyrosine-protein kinase activity. SIZE: 993 amino acids; 112903 Da SUBUNIT: Interacts with FIZ1 following ligand activation (By similarity). SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Bone marrow cells. SIMILARITY: SwissProt: P36888 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 1 Ig-like C2-type (immunoglobulin-like) domain. & Contains 1 protein kinase domain.

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	The lyophilized powder, though stable at room temperature, is best stored desiccated below 0°C. Reconstitute with sterile water to a concentration of 100 mg/mL. Reconstituted GF038 should be stored in undiluted aliquots at -20°C for up to six months. This solution can be diluted into other buffered solutions. Further dilutions should be made into buffer containing carrier protein or medium containing serum.

储存和货运信息

存储条件

The lyophilized powder, though stable at room temperature, is best stored desiccated below 0°C. Reconstitute with sterile water to a concentration of 100 mg/mL. Reconstituted GF038 should be stored in undiluted aliquots at -20°C for up to six months. This solution can be diluted into other buffered solutions. Further dilutions should be made into buffer containing carrier protein or medium containing serum.