merck millipore,默克密理博,FCMAB192F,Milli-Mark™ Anti-CD30-FITC Antibody, clone Ber-H2

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
H	FC	M	FITC	Monoclonal Antibody

描述
产品目录编号	FCMAB192F
商名	Milli-Mark
描述	Milli-Mark™ Anti-CD30-FITC Antibody, clone Ber-H2
Alternate Names	Ki-1 antigen Tumor necrosis factor receptor superfamily member 8 CD30L receptor Lymphocyte activation antigen CD30
背景信息	CD30 is a transmembrane cytokine receptor belonging to the tumor necrosis factor (TNF) receptor superfamily. Mature CD30 has a molecular mass of 120 kDa and is derived from a 90 kDa precursor protein (de Bruin, 1995). The extracellular domain of CD30 is homologous to that of TNF receptor superfamily members, whereas there is no homology in teh cytoplasmic domain, suggesting major differences in signaling mechanisms (Falini, 1995). CD30 expression is found on Hodgkin and Reed-Sternberg (H-RS) cells, and on activated B and T lymphocytes (de Bruin, 1995). The antibody from the Ber-H2 hybridoma cell line was included in the Fourth International Workshop on Human Leukocyte Differentiation Antigens and was found to belong to the CD30 cluster (Schwarting, 1989).

产品信息
格式	FITC
控制	Jurkat cells
演示	Purified Mouse monoclonal IgG1 conjugated to FITC in 0.05M Tris-HCl buffer with 1% BSA, Sodium Azide at 0.097% at pH 7.2.

应用
应用	Milli-Mark Anti-CD30-FITC Antibody, clone Ber-H2 detects level of CD30 & has been published & validated for use in FC.
主要应用	Flow Cytometry

生物信息
免疫原品种	Co-cell line established from a human with Hodgkin's disease of T-cell lineage.
克隆	Ber-H2
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Mouse
特异性	Antibody recognizes Human CD30 antigen.
同种型	IgG1κ
品种反应性	Human
Species Reactivity Note	Tested and passed on Human.
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_001234
Entrez基因汇总	The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
纯化方法	Protein A Purified
UniProt编号	P28908
UniProt汇总	Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B.

产品使用声明
质量保证	Evaluated by flow cytometry using Jurkat cells
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain refrigerated at 2-8°C protected from light in undiluted aliquots for up to 6 months from date of receipt.

包装信息
数量	100 tests

merck millipore,默克密理博,FCMAB192F,Milli-Mark™ Anti-CD30-FITC Antibody, clone Ber-H2

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