merck millipore,默克密理愽
  • merck millipore,默克密理博,CBL589F,Anti-Integrin αIIb Subunit Antibody, clone PM6/248, FITC conjugated

  • merck millipore,默克密理博,CBL589F,Anti-Integrin αIIb Subunit Antibody, clone PM6/248, FITC conjugated

    产品名称：Anti-Integrin αIIb Subunit Antibody, clone PM6/248, FITC conjugated
    产品型号：CBL589F
    This Anti-Integrin αIIb Subunit Antibody, clone PM6/248, FITC conjugated is validated for use in FC, IF for the detection of Integrin αIIb Subunit.

    merck millipore,默克密理博,CBL589F,Anti-Integrin αIIb Subunit Antibody, clone PM6/248, FITC conjugated

  • 产品介绍
  • merck millipore,默克密理博,CBL589F,Anti-Integrin αIIb Subunit Antibody, clone PM6/248, FITC conjugated

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Bab, HFCMFITCMonoclonal Antibody
    描述
    产品目录编号 CBL589F
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Integrin αIIb Subunit Antibody, clone PM6/248, FITC conjugated
    Alternate Names
    • CD41
    产品信息
    格式 FITC
    演示 The monoclonal is presented at a concentration of 100 tests/1 mL in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. We recommend that each laboratory determine an optimum working titre for use in its particular application.
    应用
    应用 This Anti-Integrin αIIb Subunit Antibody, clone PM6/248, FITC conjugated is validated for use in FC, IF for the detection of Integrin αIIb Subunit.
    主要应用
    • Flow Cytometry
    应用说明 Identification of the alpha-integrin chain of gpIIb/IIa expression on platelets, megakaryocytes and monocytes by indirect immunofluorescence staining

    Acute leukaemia phenotyping

    Studies of Glanzmann's thrombasthenia where gpIIb/IIIa is absent or significantly reduced

    Ligand binding occurs in part via an RGD sequence which is known to be of importance for certain other adhesion interactions with extracellular proteins

    Optimal working dilutions must be determined by the end user.
    生物信息
    克隆 PM6/248
    宿主 Mouse
    特异性 The antibody recognizes the human CD41 cell surface antigen, a 140kDa glycoprotein expressed by platelets and megakaryocytes. CD41 is also known as platelet glycoprotein IIb, and functions as alpha receptor for fibrinogen, fibronectin and Von Willebrand Factor. It has not been established if clone PM6/248 recognises free CD41 or CD41 only when complexed with CD61. However, antibody binding is reduced in the presence of EDTA suggesting that the epitope recognized is dependent upon an intact CD41/61 complex.

    FUSION PARTNER: SP2/0 myeloma cell line
    同种型 IgG1
    品种反应性 BaboonHuman
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_000419.3
    Entrez基因汇总 ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
    基因符号
    • ITGA2B
    • CD41B
    • HPA3
    • GP2B
    • CD41
    • GPIIb
    • ITGAB
    • GTA
    UniProt编号
    • P08514
    UniProt汇总 FUNCTION: SwissProt: P08514 # Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
    SIZE: 1039 amino acids; 113391 Da
    SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    TISSUE SPECIFICITY: Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells.
    DISEASE: SwissProt: P08514 # Defects in ITGA2B are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. This autosomal recessive disorder is the most common inherited disease of platelets. GT is characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb/beta-3 complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the glycoprotein IIb/beta-3 complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT 'variants' have normal or near normal (60-100%) expression of dysfunctional receptors.
    SIMILARITY: SwissProt: P08514 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Store at +4°C protected from light. DO NOT FREEZE. For long term use and storage aliquot conjugate into small volumes and store at +4°C for up to one year.
    包装信息
    数量 100 assays

    merck millipore,默克密理博,CBL589F,Anti-Integrin αIIb Subunit Antibody, clone PM6/248, FITC conjugated

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