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merck millipore,默克密理博,CBL512P,Anti-CD55 Antibody, clone 143-30, Phycoerythrin conjugated
产品名称:Anti-CD55 Antibody, clone 143-30, Phycoerythrin conjugated
产品型号:CBL512P
Anti-CD55 Antibody, clone 143-30, Phycoerythrin conjugated detects level of CD55 & has been published & validated for use in FC.
merck millipore,默克密理博,CBL512P,Anti-CD55 Antibody, clone 143-30, Phycoerythrin conjugated
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H FC M Phycoerythrin Monoclonal Antibody 描述 产品目录编号 CBL512P Replaces CBL512F 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-CD55 Antibody, clone 143-30, Phycoerythrin conjugated Alternate Names - DAF
产品信息 格式 Phycoerythrin 演示 The conjugate is supplied as a 100 test vial in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. For flow cytometry we recommend using 10μL of conjugate per test. 应用 应用 Anti-CD55 Antibody, clone 143-30, Phycoerythrin conjugated detects level of CD55 & has been published & validated for use in FC. 主要应用 - Flow Cytometry
应用说明 Flow Cytometry
CD55 has reduced expression on cells from individuals with paroxysmal nocturnal haemoglobinuria
Individuals with the rare Inab phenotype have an inherited deficiency of CD55
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 PHA activated peripheral blood mononuclear cells 克隆 143-30 宿主 Mouse 特异性 This antibody is the complement regulatory protein decay accelerating factor (DAF). It is a 70 kDa glycoprotein (in erythrocytes) anchored in the membrane by a glycosylphosphatidylinositol tail. In other cells the apparent molecular weight is somewhat larger. It has a substantial content of O-glycans, and also one N-glycan. DAF binds to activated C4b or C3b complement fragments on the cell surface, preventing the assembly and accelerating the decay of both classical and alternative pathways. DAF has a wide distribution on cells in non-haemopoietic tissues, particularly epithelium and endothelium and is specifically found at the foetal-maternal interface in placenta. Soluble forms of DAF are found, for example, in plasma, saliva, urine etc.
FUSION PARTNER: NS1 myeloma cell line同种型 IgG1 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_000574.2
Entrez基因汇总 This gene encodes a protein involved in the regulation of the complement cascade. The encoded glycoprotein is also known as the decay-accelerating factor (DAF); binding of DAF to complement proteins accelerates their decay, disrupting the cascade and preventing damage to host cells. Antigens present on the DAF glycoprotein constitute the Cromer blood group system (CROM). Two alternatively spliced transcripts encoding different proteins have been identified. The predominant transcript encodes a membrane-bound protein expressed on cells exposed to plasma component proteins but an alternatively spliced transcript produces a soluble protein present at much lower levels. Additional, alternatively spliced transcript variants have been described, but their biological validity has not been determined. 基因符号 - DAF
- CD55
- CR
- TC
UniProt编号 - P08174
UniProt汇总 FUNCTION: SwissProt: P08174 # Also acts as the receptor for echovirus 7 and related viruses (echoviruses 13, 21, 29 and 33).
SIZE: 381 amino acids; 41400 Da
SUBUNIT: Monomer (major form) and non-disulfide-linked, covalent homodimer (minor form).
SUBCELLULAR LOCATION: Isoform 2: Cell membrane; Lipid-anchor, GPI- anchor.
TISSUE SPECIFICITY: Expressed on the plasma membranes of all cell types that are in intimate contact with plasma complement proteins. It is also found on the surfaces of epithelial cells lining extracellular compartments, and variants of the molecule are present in body fluids and in extracellular matrix.
DOMAIN: SwissProt: P08174 The first Sushi domain (SCR1) is not necessary for function. SCR2 and SCR4 provide the proper conformation for the active site on SCR3 (By similarity).
PTM: The Ser/Thr-rich domain is heavily O-glycosylated.
SIMILARITY: Belongs to the receptors of complement activation (RCA) family. & Contains 4 Sushi (CCP/SCR) domains.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Store at +4°C protected from light. DO NOT FREEZE. For long term use and storage aliquot conjugate into small volumes and store at +4°C. 包装信息 数量 100 tests
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