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merck millipore,默克密理博,ABT283,Anti-Cadherin-11/OB Cadherin Antibody
产品名称：Anti-Cadherin-11/OB Cadherin Antibody
产品型号：ABT283
This Anti-Cadherin-11/OB Cadherin Antibody is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of Cadherin-11/OB Cadherin.
merck millipore,默克密理博,ABT283,Anti-Cadherin-11/OB Cadherin Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABT283 描述 Anti-Cadherin-11/OB Cadherin Antibody Alternate Names - OB-cadherin
- Cadherin-11
- OSF-4
- Osteoblast cadherin
背景信息 Cadherins constitute a family of transmembrane glycoproteins involved in Ca2+-dependent cell-cell interactions. The members of this family are differentially expressed in various tissues. They function in the maintenance of tissue integrity and morphogenesis. The cadherins generally contain five extracellular repeats, a transmembrane domain and a cytoplasmic tail that binds to the catenin family of cytoskeletal anchoring proteins which also function as signal transducers. The extracellular domains are responsible for the specificity of homophilic interactions between cells expressing the same cadherin. Cadherins are divided into type I and type II subgroups. Type I cadherins include epithelial cadherin (E-cadherin, cadherin-1 or uvomorulin), neural cadherin (N-cadherin or cadherin-2), placental cadherin (P-cadherin or cadherin-3) and retinal cadherin (R-cadherin or cadherin-4). Kidney cadherin (K-cadherin or cadherin-6) and osteoblast cadherin (OB-cadherin or cadherin-11) are type II cadherins. The progression of carcinomas is associated with the loss of epithelial morphology and a concomitant acquisition of a more mesenchymal phenotype, which is thought to contribute to the invasive and/or metastatic behavior. A putative role for cadherin-11 in these late stages of tumor progression is based on the fact that migration of mesenchymal cells is facilitated when cadherin-11 is highly expressed. 产品信息 格式 Affinity Purified 演示 Purified rabbit Polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 This Anti-Cadherin-11/OB Cadherin Antibody is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of Cadherin-11/OB Cadherin. 主要应用 - Western Blotting
应用说明 Western Blotting Analysis: 2 µg/mL of a representative lot of this antibody detected Cadherin-11/OB Cadherin in 10 µg of Mouse Brain, Mouse Brain Cytosol, Mouse Brain Membrane, Mouse Brain Nuclear Extract, Mouse (Aged) Brain Frontal Cortex, and Mouse Cerebellum tissue lysate.
Immunohistochemistry Analysis: A 1:50 dilution of a representative lot of this antibody detected Cadherin-11/OB Cadherin in neurons of the human cerebral cortex and thalamus, as well as purkinje and basket cells in human cerebellum.生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the Cadherin 5 domain of Human Cadherin-11/OB Cadherin. 表位 Cadherin 5 domain 浓缩 Please refer to lot specific datasheet. 宿主 Rabbit 品种反应性 MouseHuman Species Reactivity Note Human, Mouse. Predicted to react with Rat based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_001788
基因符号 - CDH11
纯化方法 Antigen Affinity purified UniProt编号 - P55287
产品使用声明 质量保证 Evaluated by Western Blotting in Human Thalamus Tissue lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected Cadherin-11/OB Cadherin in 10 µg of Human Thalamus Tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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