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品种反应性 主要应用 宿主 格式 抗体类型 Eq, H, M, R WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABN37 描述 Anti-Homer1 Antibody Alternate Names - Homer1
- Homer protein homolog 1
背景信息 Also known as Vesl-1S, Homer1 is an activity-induced neuronal protein that is expressed at a low level in its resting state and is induced by neuronal activities such as long-term potentiation (LTP), seizure, and stimulations like inflammatory pain, depolarization, and dopamine. However, further research is still required to elucidate its mode of action, Homer1 was shown to play a role in the onset of synaptic remodeling and regulate the activity-induced biphasic changes of post- and pre-synaptic sites. 产品信息 格式 Affinity Purified 控制 - Mouse brain tissue lysate.
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-Homer1 Antibody detects level of Homer1 & has been published & validated for use in WB, IH(P). 主要应用 - Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected Homer1 in neurons of human brain tissue. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human Homer1. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes Homer1 (Vesl-1S) and its splicing variant Vesl-1L. 品种反应性 HorseHumanMouseRat Species Reactivity Note Demonstrated to react with Human, Mouse, and Rat. Predicted to react with equine based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_004263
Entrez基因汇总 This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. 基因符号 - SYN47
- HOMER1
纯化方法 Affinity purified UniProt编号 - Q86YM7
UniProt汇总 FUNCTION: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.
SUBUNIT STRUCTURE: Interacts with IFT57. Interacts with OPHN1. Isoform 1 encodes a coiled-coil structure that mediates homo- and heteromultimerization.
SUBCELLULAR LOCATION: Cytoplasm. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell junction > synapse. Note: Postsynaptic density of neuronal cells. Isoform 1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum.产品使用声明 质量保证 Evaluated by Western Blot in mouse brain tissue lysate.
Western Blot Analysis: 0.1 µg/mL of this antibody recognizes Homer1 in 10 µg of mouse brain tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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