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品种反应性 主要应用 宿主 格式 抗体类型 H ICC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABC464 描述 Anti-VAMP-3 Antibody Alternate Names - Synaptobrevin-3
- Vesicle-associated membrane protein 3
- VAMP-3
- Cellubrevin
- CEB
背景信息 VAMP-3 also known as cellubrevin is a vesicular transport protein and SNARE protein important in vesicle trafficking and exocytosis that helps regulate the release of critical components and processes such as blood clotting and inflammatory responses through the release of secretory granules and secretory vesicles. VAMP3 regulates the release of WPBs from endothelial cells. Weibel-Palade bodies (WPBs) are secretory organelles of endothelial cells that store the thrombogenic glycoprotein von Willebrand factor (vWF). Endothelial activation, for example by histamine and thrombin, triggers the Ca(2+)-dependent exocytosis of WPB that releases vWF into the vasculature and thereby initiates platelet capture and thrombus (blood clot) formation. VAMP3 is also critical to the release of proinflammatory compounds IL-6 and TNF-alpha.VAMP-3 is widely expressed in cells. 产品信息 格式 Affinity Purified 演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 This Anti-VAMP-3 Antibody is validated for use in Western Blotting and Immunocytochemistry for the detection of VAMP-3. 主要应用 - Immunocytochemistry
- Western Blotting
应用说明 Western Blotting Analysis: A 1:500 dilution from a representative lot detected VAMP-3 in 10 µg of Huvec and human brain tissue lysate.
Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected VAMP-3 in PANC-1 cells.生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human VAMP-3 near the N-terminus. 表位 Near N-terminus 浓缩 Please refer to lot specific datasheet. 宿主 Rabbit 品种反应性 Human Species Reactivity Note Human. Predicted to react with Rat, Mouse based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_004772
基因符号 - SYB3
- VAMP3
纯化方法 Affinity purified UniProt编号 - Q15836
产品使用声明 质量保证 Evaluated by Western Blotting in PANC-1 cell lysate.
Western Blotting Analysis: A 1:500 dilution of this antibody detected VAMP-3 in 10 µg of PANC-1 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µL
上一件merck millipore产品：merck millipore,默克密理博,9710-OP,OmniPur Xylene Cyanol FF - CAS 2650-17-1 - Calbiochem
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