merck millipore,默克密理愽
  • merck millipore,默克密理博,ABC458,Anti-Thymidylate Kinase/TMPK Antibody

  • merck millipore,默克密理博,ABC458,Anti-Thymidylate Kinase/TMPK Antibody

    产品名称：Anti-Thymidylate Kinase/TMPK Antibody
    产品型号：ABC458
    Anti-Thymidylate Kinase/TMPK Antibody is a rabbit polyclonal antibody, validated for use in western blotting & IP.

    merck millipore,默克密理博,ABC458,Anti-Thymidylate Kinase/TMPK Antibody

  • 产品介绍
  • merck millipore,默克密理博,ABC458,Anti-Thymidylate Kinase/TMPK Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 ABC458
    描述 Anti-Thymidylate Kinase/TMPK Antibody
    Alternate Names
    • dTMP kinase
    • Thymidylate kinase
    背景信息 TMPK, also known as dTMP kinase, and encoded by the gene DTYMK/CDC8/TMPK/TYMK, is a key enzyme for pyrimidine synthesis that catalyzes the phosphorylation of thymidine 5'-monophosphate (dTMP) to form thymidine 5'-diphosphate (dTDP). TMPK has important functions in cell proliferation and DNA replication, and the synthesis of dTDP is unique because it requires TMPK. All other dNDPs are directly produced by ribonucleotide reductase (RNR). Thus, TMPK is well recognized as a potential drug target for many diseases and disease agents including viruses. TMPK is currently a target of anti-HIV nucleoside therapy, and TMPK is also a validated target for antibiotic development against resistance strains of bacteria and parasites, and research demonstrates that it may also be a good target for the anticancer agent doxorubicin cancer cells. Expressed by virtually all cells it is localized to cell cytoplasm with only traces found in Golgi, mitochondria and nuclei.
    产品信息
    格式 Purified
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-Thymidylate Kinase/TMPK Antibody is a rabbit polyclonal antibody, validated for use in western blotting & IP.
    主要应用
    • Western Blotting
    应用说明 Western Blotting Analysis: A representative lot from an independent laboratory detected Thymidylate Kinase/TMPK in MDA-MB231, MCF-7, H184B5F5/M10 cell lysates (Hu, C. M., et al. (2012). Cancer Cell. 22(1):36-50.).

    Immunoprecipitation Analysis: A representative lot from an independent laboratory immunprecipitated Thymidylate Kinase/TMPK from MCF-7, H184B4F5/M10, and MCF-10A cell lysates (Ke, P. Y., et al. (2005). Genes Dev. 19(16):1920-1933.).

    Western Blotting Analysis: A representative lot from an independent laboratory detected Thymidylate Kinase/TMPK in MCF-7, H184B4F5/M10, and MCF-10A cell lysates (Ke, P. Y., et al. (2005). Genes Dev. 19(16):1920-1933.).
    生物信息
    免疫原品种 GST-tagged recombinant protein corresponding to human Thymidylate Kinase/TMPK.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    品种反应性 Human
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_036277
    基因符号
    • TYMK
    • DTYMK
    • CDC8
    • TMPK
    纯化方法 Protein A purified
    UniProt编号
    • P23919
    产品使用声明
    质量保证 Evaluated by Western Blotting in Jurkat cell lysate.

    Western Blotting Analysis: 2 µg/mL of this antibody detected Thymidylate Kinase/TMPK in 10 µg of Jurkat cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,ABC458,Anti-Thymidylate Kinase/TMPK Antibody

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