merck millipore,默克密理愽
  • merck millipore,默克密理博,ABC259,Anti-Death-associated protein 1 Antibody

  • merck millipore,默克密理博,ABC259,Anti-Death-associated protein 1 Antibody

    产品名称：Anti-Death-associated protein 1 Antibody
    产品型号：ABC259
    This Anti-Death-associated protein 1 Antibody is validated for use in western blotting & IHC for the detection of Death-associated protein 1.

    merck millipore,默克密理博,ABC259,Anti-Death-associated protein 1 Antibody

  • 产品介绍
  • merck millipore,默克密理博,ABC259,Anti-Death-associated protein 1 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    H, MIHC, WBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 ABC259
    描述 Anti-Death-associated protein 1 Antibody
    Alternate Names
    • DAP-1
    • Death-associated protein 1
    背景信息 The protein Death-associated protein 1 or also known as DAP-1/DAP1 and encoded by the gene DAP/DAP1 is a negative regulator of autophagy. The link of DAP1 to autophagy was recognized because in DAP1 knockdowns there was enhanced autophagic flux and DAP1 displayed a rapid decline in its phosphorylation in response to amino acid starvation, a key inducer of autophagy. Mapping of the phosphorylation sites and analysis of phosphorylation mutants indicated that DAP1 is functionally silenced in growing cells through mTOR-dependent phosphorylation on Ser3 and Ser51. Inactivation of mTOR during starvation caused a rapid reduction in these phosphorylation sites and converted the protein into an active suppressor of autophagy. These results are consistent with a "Gas and Brake" model in which mTOR inhibition also controls a buffering mechanism that counterbalances the autophagic flux and prevents its over activation under nutrient deprivation. DAP1 is also involved in mediating interferon gamma induced cell death, which appears to often be mediated by autophagy, and recently it has been shown to be important in regulating myogenesis and the apoptosis of satellite cells during development. DAP1/Death-associated protein 1 is regulated by phosphorylation; phosphorylation by MTOR inhibits the suppressive activity of DAP toward autophagy. DAP1 is expressed by most cells and up regulated in many cancer cells as well.
    产品信息
    格式 Affinity Purified
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 This Anti-Death-associated protein 1 Antibody is validated for use in western blotting & IHC for the detection of Death-associated protein 1.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    应用说明 Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected Death-associated protein 1 in human prostate cancer and normal testis tissues. (Note: It is recommended for end-users to perform a 1:1,000 dilution for enhanced performance.)
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to the unknown of human Death-associated protein 1.
    浓缩 1.0 mg/mL
    宿主 Rabbit
    品种反应性 HumanMouse
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_004385
    基因符号
    • DAP1
    • DAP
    纯化方法 Affinity purified
    UniProt编号
    • P51397
    产品使用声明
    质量保证 Evaluated by Western Blotting in serum starved and control NIH/3T3 cell lysate.

    Western Blotting Analysis: 1 μg/mL of this antibody detected Death-associated protein 1 in serum starved NIH/3T3 cell lysate and demonstrated a loss of signal in control NIH/3T3 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,ABC259,Anti-Death-associated protein 1 Antibody

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