merck millipore,默克密理愽
  • merck millipore,默克密理博,AB9500,Anti-Vasopressin V2 Receptor Antibody

  • merck millipore,默克密理博,AB9500,Anti-Vasopressin V2 Receptor Antibody

    产品名称：Anti-Vasopressin V2 Receptor Antibody
    产品型号：AB9500
    This Anti-Vasopressin V2 Receptor Antibody is validated for use in IH(P) for the detection of Vasopressin V2 Receptor.

    merck millipore,默克密理博,AB9500,Anti-Vasopressin V2 Receptor Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB9500,Anti-Vasopressin V2 Receptor Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HIH(P)RbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB9500
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Vasopressin V2 Receptor Antibody
    产品信息
    格式 Affinity Purified
    演示 Affinity purified immunoglobulin. Liquid in PBS, pH 7.7 with 0.01% sodium azide.
    应用
    应用 This Anti-Vasopressin V2 Receptor Antibody is validated for use in IH(P) for the detection of Vasopressin V2 Receptor.
    主要应用
    • Immunohistochemistry (Paraffin)
    应用说明 Immunohistochemistry on paraffin embedded tissue sections.

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Synthetic peptide from the 3rd cytoplasmic domain of human Vasopressin V2 Receptor.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes Vasopressin V2 Receptor.
    品种反应性 Human
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_000054.2
    Entrez基因汇总 This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing.
    基因符号
    • MGC138386
    • AVPR2
    • DI1
    • V2R
    • MGC126533
    • DIR
    • DIR3
    • ADHR
    • NDI
    UniProt编号
    • P30518
    UniProt汇总 FUNCTION: SwissProt: P30518 # Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
    SIZE: 371 amino acids; 40279 Da
    SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
    TISSUE SPECIFICITY: Kidney.
    DISEASE: SwissProt: P30518 # Defects in AVPR2 are the cause of nephrogenic syndrome of inappropriate antidiuresis (NSIAD) [MIM:300539]. This disorder is characterized by an inability to excrete a free water load, with inappropriately concentrated urine and resultant hyponatremia, hypoosmolarity, and natriuresis. & Defects in AVPR2 are a cause of X-linked nephrogenic diabetes insipidus, type I (NDI) [MIM:304800]. It is characterized by excessive water drinking (polydypsia) and urine excretion (polyuria) and fail to concentrate urine in response to vasopressin. Most cases of NDI appear to have an X-linked recessive pattern of inheritance.
    SIMILARITY: SwissProt: P30518 ## Belongs to the G-protein coupled receptor 1 family.
    产品使用声明
    销售限制 This product is not available for sale in Japan.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -70°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 50 µg

    merck millipore,默克密理博,AB9500,Anti-Vasopressin V2 Receptor Antibody

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